Types of Mutations (8)
Point mutation
Insertion
Deletion
Gene Duplication
Inversion
Frameshift mutation
Chromosome Fusion
Genome Duplication
Meiosis
Recombination of genetic material
Population Genetics
The study of the distribution and frequencies of genotypes and alleles in population
Harvey-Weinberg Equilibrium
Theoretical concept of no evolutionary changes.
Able to predict allele frequencies.
Conditions for HWE
Population is infinitely large
Genotypes do not confer differences in fitness
No mutation
Mating is random
No migration
Fitness (W)
The survival and reproductive success of an individual with a particular phenotype
Components of Fitness
Survival to reproductive age
Mating success
Fecundity
Relative Fitness (w)
Contribution of individuals with one genotype compared with the average contribution of all individuals in the population
Average Excess Fitness
Difference between relative contribution of individuals with one genotype and the average fitness of the populations as a whole
Natural selection is more effective in _____
Large populations, because drift is less likely
Genome Sequencing
Can pinpoint genetic mechanisms of evolution
Pleiotropy
A single gene or mutation influences multiple phenotypic traits
Antagonistic Pleiotropy
Beneficial effects for one trait but detrimental effects for other triats
Negative Frequency-Dependent Selection
Common phenotypes are selected against and rare phenotypes are favoured
Heterozygote Advantage
Heterozygosity confers greater fitness than homozygotes
Mutation-Selection Balance
Equilibrium frequency reached through tug-of-war between negative selection on deleterious alleles and new mutations.
Explains persistence of deleterious mutations in populations
Inbreeding
Brings recessive deleterious allele together
Inbreeding Depression
the reduction in biological fitness due to inbreeding
Inbreeding Coefficient
F = the probability that two alleles at any locus of an individual are identical by descent
Gene Expression
Process by which information from a gene is transformed into a product
Order of RNA Processes
Epigenetic
The functional modifications to DNA that don’t involve changes to the sequences of nucleotides.
The study of the heritability of these modifications
Epistasis
When the effects of an allele at one genetic locus are modified by alleles at one or more other loci
Additive
Describes an allele that yields twice the phenotypic effect when two copies are present at a given locus. Not influenced by the presence of other alleles.