1
Q
What is sarcoidosis
A
- Inflammatory process that PRODUCES GRANULOMAS, which may be in various organs
- symptoms of sarcoidosis stem from the CLUMPING OF GRANULOMAS, which affect its ability to function
- More common in African Americans
2
Q
What are the two phases of granulomas
A
- Active Phase = the granulomas form and grow in this phase, symtpoms develop and scar tissue can form
- INactive phase: inflammation subsides, the granulomas shrink or stay the same size. But the scares remain and cotninue to produce symtpoms
3
Q
describe the 5 stages of Sarcodosis
A
- Stage 0 = normal
- stage I = isolated bilateral thoracic lymphadenopathy
- Stage II = bilateral hillar lymphadenopathy plus lung parenchymal infiltration
- Stage III = parenchymal infiltration
- Stage IV = advanced parenchymal disease, including overt pulmonary fibrosis
4
Q
what are the pulmonary symptoms of sarcodosis
A
- Hemoptysis
- shortness of breath
- dry cough
- wheezing
- pain in the chest
5
Q
Describe the lymph node findings in Sarcodosis
A
- lymph nodes are enlarged tender lymph nodes (present within the neck, chest, chin, armpits, and groin)
6
Q
what are the dermatologic manifestations of sarcodosis
A
- various types of bumps, ulcers that are usually itchy
- painful bumps (at the ankles and shin) known as ERYTHEMA NODOSUM
- difiguring sores (nasal passages, cheeks, ears, eyelids, and fingers) CALLED LUPUS PERNIO
7
Q
describe ocular involvmeent of sarcodosis
A
- Optic neuritis
- keratoconjunctivitis
- uveitis
8
Q
describe tx goals
A
- management of systemic manifestations (improve organ function, relieve symptoms, sfrink granulomas)
- Meds = prednisone, plaquenil, nsaids, cyclophosphamide etc
