biochem

Question 1

how does a competitive inh affect Km, Vmax? non-competitive inh?

Answer 1

• competitive: increase Km, same Vmax

- noncomp: same Km, decrease Vmax

Question 2

protein glycosylation: location

Answer 2

• ER: during translation (N-linked)

- Golgi: after translation (O-linked), trim N/O

Question 3

I cell dz: pathophys

Answer 3

impaired phosphorylation of mannose on glycoproteins –> cannot route to vacuole –> undegraded mole accum in lysosome

Question 4

what stimulates PEPCK expression?

Answer 4

• cortisol: cortisol receptor

- glucagon: cAMP/CREB

Question 5

vitB12 def: who?

Answer 5

• strict vegan

- alcoholic

Question 6

vitB12 def –> leads to?

Answer 6

• bilat peripheral neuropathy
• methylmalonic aciduria
• megaloblastic anemia (folate trap hypothesis)

Question 7

von Gierke

Answer 7

glucose 6 phosphate deH

• hypoglycemia
• lactic acidosis
• hepatomegaly
• hyperlipid
• hyperuric

Question 8

Pompe

Answer 8

lysosomal a-glucosidase

• cardiomegaly
• muscle weak

Question 9

Cori

Answer 9

debranching enzyme

• mild hypoglycemia
• liver enlrg

Question 10

McArdle

Answer 10

muscle phosphorylase

• muscle cramp/weak w exertion
• myoglobinuria