antibodies
specific protein in the blood that can react with and combine with its specific antigen
antigen
antigen in our blood called ABO antigen blood group
abo antigen are genetically determined
when you get a transfusion reaction 2 things can happen
agglutination: causes RBCs to clump together causing clogged capillaries and block blood flow
or the transfused RBCs will brake apart which would also cause clotting and depolarization
Genetics of ABO blood group gene and alleles
in a blood type there is one gene and three possible alleles
from parent, you get one gene along with one allele each
RH group
Rh is another type of antigen called D antigen that can be present (+) or not (-)
85% of humans have this blood type and it is only genetically determined and only found in blood cells
- if a person is - they onlt can develop an antibody if RH if exposed to RH -
Erythroblastosis fetalis
when RH- mother gets pregnant with RH+ of the second time, the proteins from the mother cross the placenta along with the RH- antibodies causing them to attack the baby’s blood
RhoGam
drug that you can now administer into the mother before the delivery to inhibit the making of antibodies of RH