case 5 overview

Question 1

Describe atheromatous coronary artery disease.

Answer 1

• Multiple risk factors
• Endothelial injury (risk factors)
• ‘Fatty steak’ formation
• Role of LDL cholesterol
• Macrophage accumulation and
  inflammation
• Smooth muscle migration
• Progressive narrowing of lumen
  with reduction in blood delivery
• Microcirculatory compensation.

Question 2

What are some therapeutic targets in IHD?

Answer 2

• Atheromatous disease
• Risk factors for atheroma
  including lifestyle
• Thrombosis
• Blood flow / ischaemia
• Left ventricular function.