Ceftriaxone

Question 1

Ceftriaxone
Type

Answer 1

3rd generation cephalosporin antibiotic

Question 2

Ceftriaxone
Presentation

Answer 2

1g ceftriaxone powder for reconstitution

Question 3

Ceftriaxone
Actions

Answer 3

1. Broad spectrum antibiotic - especially effective against gram-negative bacteria (eg. meningococcus)
2. Effective crossing the blood-brain barrier

Question 4

Ceftriaxone
Use

Answer 4

Suspected meningococcal disease, in acutely ill patients

Question 5

Ceftriaxone
Adverse Effects

Answer 5

1. Hypersensitivity reactions (not common)
2. Diarrhoea
3. Skin rash

Question 6

Ceftriaxone
Contraindications

Answer 6

Known hypersensitivity to cephalosporins

Question 7

Ceftriaxone
Precautions

Answer 7

It is possible that 20% patients with a penicillin allergy may be sensitive to ceftriaxone

Special note: an incident reports should be submitted to CGU in administered.

Question 8

Ceftriaxone
Dose

Answer 8

Adult and Paed:
50mg/kg, to a total of 2g - IV preferred.
make up to 10ml with normal saline - give slowly over 2-4mins.
May be administered IM - give two injections if dose over 1g (i.e. over 3ml volume)