Ondansetron

Question 1

Ondansetron
Type

Answer 1

Potent anti-nauseant and antiemetic

Question 2

Ondansetron
Presentation

Answer 2

4mg in 2ml - plastic or glass ampoule
4mg - orally disintegrating tablet (ODT)

Question 3

Ondansetron
Actions

Answer 3

1. Potent, highly specific and selective serotonin 5-HT receptor antagonist
2. Precise mode of action in control of nausea and vomiting is not known. likely to have actions peripherally and in the central nervous system.
3. Maximum effect is approximately 10mins following IV adminstration
4. Hepatic metabolism

Question 4

Ondansetron
Use

Answer 4

For the prevention or treatment of nausea and vomiting

Question 5

Ondansetron
Adverse effects

Answer 5

FODATH
1. Flushing of the skin
2. Occasional reaction at the site of IV injection
3. Drowsiness
4. Anxiety and agitation
5. Transient visual disturbances
6. Headache

Question 6

Ondansetron
Contraindications

Answer 6

Known hypersensitivity

Question 7

Ondansetron
Precations

Answer 7

Not recommended in pregnancy

Question 8

Ondansetron
Dose Adult

Answer 8

IV: 8mg slowly over 2 mins. May be administered IM if necessary. single dose only
ODT: 8mg sublingually - single dose only.

Question 9

Ondansetron
Dose Paed

Answer 9

IV: 0.1mg/kg (max 4mg) - slowly over 2mins. May be administered IM if necessary.
repeat once if required, after approx 10mins
ODT:
>6months-3yrs 2mg - single dose
4yrs-9yrs - 4mg - single dose
>10yrs - 8mg - single dose