Central synapses

Question 1

Temporal summation

Answer 1

2 signals from same neuron
Same place, different time
Larger EPSP

Question 2

Spatial summation

Answer 2

2 neurons send AP at same time
Different place
Larger EPSP

Question 3

EPSP are found in _
IPSP are found in _

Answer 3

• Axodendritic(spines)
• Dendrite shaft, axoaxonic(axon), axosomatic(neuron body)

Question 4

NMDA receptors are _ gated

Answer 4

Ligand(glu) and voltage

Question 5

NMDA is a coincidence detector

Answer 5

Opens when pre and postsynaptic membranes are depolarized at the same time

Question 6

How does NMDA open

Answer 6

Glu enters, AMPA takes in Na+ > depolarize > NMDA opens

Question 7

NMDA are permeable to which ion?
What does it do?

Answer 7

• Ca2+
• Activates kinases that insert more AMPA receptors > long term potentiation

Question 8

GABAa is a _ receptor
Which ion?
GABAb is a _ receptor
How does it act?

Answer 8

• Ionotropic
• Cl-
• Metabotropic
• Presynaptic membrane:
  Inhibits Ca2+ channels > less GABA release(autoinhibition)
  Postsynaptic membrane:
  Opens K+ channels > hyperpolarization

Question 9

Location:
Cholinergic Ach
Norepinephrine
Serotonin
Dopamine
Histamine

Answer 9

• Septa nuclei, nucleus basalis
• Locus coeruleus
• Raphe nuclei
• Substantia nigra, ventral tegmental area
• Tuberomammillary nucleus