_ CT in skin
_ CT in tendons
- Loose
- Fibrous
ECM is _ + _
- Protein fibers, ground substance
Strongest cartilage is _
Fibrocartilage
Most numerous CT is _
Fibroblasts
_ secrete protein fibers and ground substance
_ is the inactive form
- Fibroblasts
- Fibrocytes
Macrophages are derived from
Blood cells(monocytes)
Adipocytes are 2 types _, _
-Unilocular(white), multilocular(brown)
_ occur in bone marrow and stimulate inflammation after injury
Mast cells
Adult stem cells are 2 types
- Mesenchymal > replace CT after injury
- Hematopoietic > rise to all wandering cells
_ most abundant fiber of CT and protein in body(30%)
It is composed of _
- Collagen
- Tropocollagen
Type I collagen:
Type II:
Type III
Type IV:
- Heterotrimeric, CT proper
- Homotrimeric, cartilage
- Homo, Reticular fibers
- Homo, Basal lamina, no 68nm banding
Classes of collagen(6):
-Fibrillar(1,2,3,5,11)
- FACIT(9,12,14,16)
- Hexagonal(8,10)
- Transmembrane(13,17,23)
- Multiplexins(15,18)
- Basement membrane(4,6,7)
_ main source of collagen and secrete _
Fibroblasts, procollagen
T/F: Synthesis of collagen is intracellular
False. Collagen molecule > intra
Fibrillogenesis > extra
Elastic fibers made of (2)
- Central core elastin(desmosine, isodesmosine)
- Surrounding fibrillin
Abnormal fibrillin expression >
Marfan syndrome
_ helps bind cells to CT fibers
Mixture of _ + _
- Ground substance
- Proteoglycans, GAG’s
Proteoglycans:
_ has 1 GAG
_ has +200 GAG’s
_ is membrane-bound
_, _ have identical GAG’s
- Decorin
- Aggrecan
- Syndecan
- Fibroglycan, versican
_ responsible for physical properties of ground substance
Consist of
Examples …
- GAG’s
- GlcNac/GalNac + uronic acid
- Dermatan sulfate, hyaluronan
T/F: All GAG’s are synthesized as post-translational covalent modifications of proteoglycans
False. Not hyaluronan. It is in the ECM as a free CBHY.
Binds proteoglycans by linker proteins
Hyaluronan forms _ that is found in _
- Proteoglycan aggregates
- Cartilage ground substance
_ stabilize ECM and connect it to cell.
Examples…
- Multi-adhesive glycoproteins
- Fibronectin, laminin, entactin
T/F: ECM is cellular material around cells.
False. Non-cellular
