NM transmission

Question 1

Synaptic cleft has a specialized from of ECM called _

Answer 1

Synaptic basal lamina

Question 2

T/F: EPP is propagated passively with decrement to the Na+ channels

Answer 2

True

Question 3

Myasthenia gravis?
Lambert-Eaton syndrome?

Answer 3

• Autoantibodies against Ach receptors
• Autoantibodies against voltage gated Ca2+ channels
  LE leads to autonomic dysfunction

Question 4

Ach-E inhibitors(2)

Answer 4

• Neostigmine, prostigmine(reversible)
  -Organophosphates(irreversible)

Question 5

NMJ blockers(2)

Answer 5

Depolarizing: Sunccinylcholine
> No repolarization > one contraction
Non depolarizing: Curare, Rocuronium
> Competitively blocks Ach receptor > no contraction