Ch 68: OA

Question 1

What is Carprofen?

Answer 1

Propionic acid derived NSAID
Cox2 selective with Cox1:Cox2 of 17
Side effect- limited GI toxicity

Question 2

What is Deraxocib

Answer 2

Coxib class
Once a day
Metabolized by liver- elimination half life 3 hrs
excreted in feces as both meabolism and unchanged drug

Question 3

What is Etodolac

Answer 3

Indole acetic acid derivative
Cox1 and Cox 2 inhibition (primarily cox 1)
Removed from body via biliary excretion but does not undergo enterohepatic recirculation
Long half life 9-14 hrs (once a day dose)
Associated with KCS

Question 4

What is Firocoxib

Answer 4

Pyridylsulfone
Cox 2 specific
Cox1:2 342: 430
Once daily

Question 5

What is ketoprofen

Answer 5

Cox 1 selective
propionic acid subclass of carboxylic acid derivitive
once daily

Question 6

What is Mavocoxib

Answer 6

preferential cox 2 inhibitor with Cox1:Cox 2 21
Eliminated via biliary tract almost unchanged
terminal elimination half life 40 days
2mg/kg for 7 doses

Question 7

What is meloxicam

Answer 7

Cox 2 selective
Oxicam group
Cox 1:2 is 3
low GI and renal toxicity
Half life 20-30 hrs
approvced or treatment in cats at 0.05mg/kg

Question 8

What is phenylbutazone

Answer 8

only in europe
cox1:2 –> 2.64 (Slight cox 2 selective)
toxicity: hemorrhage, biliary stasis, hepatitis, renal failure, blood dsycrasies

Question 10

What is Robenacoxib

Answer 10

europe
highly cox 2 (140 ratio)
metabolized in liver with 1/2 life 1 hr
excreted in biliary system and remainder in kidney

Question 11

What is Tepoxalin

Answer 11

Non selective Cox inhibitor and also inhibits Lipoxygenase 5
Been shown to ameliorate collagen degredation in vivo

Question 12

What is Tolfenamic Acid

Answer 12

analfesic and antypyretic properties

Question 13

What are the causative organisms of infective arthritis

Answer 13

Causative agents = S. intermedius, S. aureus, beta-hemolytic Strep (P. multocida and Bacteroides in cats due to their oral flora)

Question 15

What are the types of IMPA

Answer 15

Type I- Idiopathic (accounts for 50% of nonerosive IMPA cases)
Chemotherapeutic suppression (prednisolone) - 56% cure in dogs
Type II- Associated with infection remote from joint (accounts for 25% of nonerosive IMPA cases)
Type III- GI Related
Type IV- Paraneoplastic

Question 16

What is the synovial fluid of normal, OA, rhematoid arthritis, nonerosive IMPA, and infective OA

Answer 16