what are 3 functions of mucus
-protective
-lubricating
-water proofing
-entraps microorganism
which diseases cause poor secretion clearance in the body?
-CF
-chronic bronchitis
-pneumonia
-primary ciliary dyskinesia
-asthma
-bronchiectasis
-DPB( diffuse panbronchiolitis)
true or false:
submucosal glands are responsible for providing secretions
true
what is the cholinergic response to mucociliary clearance
-increase ciliary beat
-increase mucus production
-increase transport
what color would the sputum be if it contains neutrophils
purulent and green
what are the 4 physical properties of mucus
-viscocity
-elasticity
-cohesivity
-adhesivity
what are the mucoactive agents available for aerosol administration
-mucolytic
-expectorants
-mucoregulatory agents
-n-acetylcysteine (mucomyst)
-dornase alfa- pulmozyme
-aqueous aerosols- saline & hypertonic saline
*what is the most important side effects of mucomyst? what medication must we always administer with it?
-bronchospasms
-administer with a bronchodilator
what is the trade name for pulmozyme
dornase alfa
what is the definition of expectorants
-agents that increase volume or hydration of airway secretions
*hypertonic saline
what disease do we treat with Dornase alfa and why?
-CF
breaks down DNA reducing viscosity and adhesivity
-clearance of purulent secretions
-reduce frequent respiratory infections with parenteral anitbiotics
-improve or preserve pulmonary function
which type of medication cannot be given with acetylcysteine (mucomyst)
antibotics
true or false:
dornase alfa reduces the viscocity of sputum by breaking down DNA content in the sputum
true
how does N-acetylcysteine work
-decrease viscosity of secretions
-breaks down bonds in mucus molecules making it less sticky and easier to expel
- helps w/ acetaminophen OD
dose:10 or 20%
what is the most common side effect of Dornase alfa
voice alteration
what is hypertonic saline used for
induce cough and helps liquify secretions
what is an insufflation-exsufflation device? what type of disease do we treat with this device
cough assist
-CF
what are mucoactive drugs? what are contraindications for mucoactive therapy?
any medication of drugs that have an affect on mucus secretion
contraindications:
-cant protect airways
-reactive airway disease
-pulmonary hemorrhage
when should mucoactive therapy be considered
-decrease infection and inflammation
what is the definition of phlegm
purulent material in airways
what is the definition of sputum
expectorated phlegm that contains respiratory tract, oropharyngeal, nasopharyngeal secretions, bacteria, products of inflammation including polymeric dna and actin
what is the definition of mucus
secretions from goblet cells and submucosal glands composed of water,proteins, and glycosylated mucin
what is the definition of mucoregulatory drugs
drugs that reduce the volume of airway mucus secretions
-reduces how much mucus is being made in the first place
*steroid,-decrease inflammatory response, reduce mucus production
*anticholinergics-reduce glandular secretions
*macrolid antibotics-decrease hyperimmunity or inflammation,lowers mucus productiin
what is the definition of mucokinetic drugs
medications that increase cough or cilliary clearance of respiratory secretions
-help move mucus
*bronchodilators, surfactant
