Epidemiology > Circovirus > Flashcards

Circovirus Flashcards

(54 cards)

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1
Q

Circovirus General Characteristics

A

ssDNA,, Icosahedral, no envelope, replicated in rapidly dividing cells, stenoxen, long life immunity, highly resistant

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2
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Most susceptible

A

1.5-4mo piglets

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3
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Target Organs

A
  • Lung, thymus, spleen, BM, liver, kidney, heart, brain
  • Dividing cells: Macrophages, APCs, Epithelium
  • Fetus: thymus&heart
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4
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Clinical Signs

A
  • Sudden death
  • Progressive weight loss
  • Non-specific CS
  • Enteric&respiratory signs
  • Aneamia
  • CNS signs
  • Jaundice , rough hair
  • Subclinical infection: dec. CD8+ ->recovery
  • PMWS: Lymphoid depletion, thymus atrophy, hepatitis, entreitis, pneumonia
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5
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Pathology & Histopathology

A
  • LNs: elnarged, hemorrhagic iguinal&mestenteric
  • Lungs: intestitial edema, pneumonia
  • General bad condition of carcass
  • White foci in kidney
  • Gastric ulcers
  • Hepatomagaly/atrophy, Jaundice, ascites
  • Strawberry heart with flaccid myocardium
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6
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Diagnosis

A

CS, PM, ELISA, PCR, IF

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7
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Treatment

A

No effective treatment!

Ab

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8
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Prevention & Immunity

A
  • Inactivated/recombinant vaccine (capsid protein)
  • No live vaccine!
  • Sow: protects from reproductional disorders, gives enough protection to piglets
  • Piglets:after weaning

*Colostral Ab: 4-12w

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9
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Pathogenesis

A

Oronasal -> replicates in monocytes in nasal mucosa >lung->thymus, spleen-> BM, liver, kidney heart, brain

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10
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Most susceptible

A

30-100kg pigs
>1.5mo
*wild boars,ru, rodents are reservoirs

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11
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Occurence

A

Sporadic

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12
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Occurence

A
  • Epidemic in Europe and Asia

* Sporadic in North America

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13
Q

PMWS: Post-weaning Multi-systemic Wasting Syndrome

Spread

A

Oral/nasal/sexual

Contact with sick animal, respiratory secertions, saliva, urine, feces, sperm

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14
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Spread

A

Oral/nasal/sexual

Contact with sick animal, respiratory secertions, saliva, urine, feces, sperm

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15
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Pathogenesis

A

Not fully understood

*Type III hypersensitivity -Immunocomplex deposition in skin, kidney, BV

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16
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Clinical signs

A
  • Progressive weight loss
  • Multifocal, circular red skin lesion->darken->scar
  • Hemorrhages throughout the body
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17
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Pathology

A
  • Hemorrhagic enlarged grayish kidneys.
  • Thrombosis, systemic narcotizing vasculitis
  • Exudative glomerulonephritis
  • Bronchopneumonia
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18
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Diagnosis

A

CS, PM, ELISA, PCR, IF

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19
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Treatment

A

No effective treatment

Ab

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20
Q

PDNS: Porcine Dermatitis Nephropathy Syndrome

Prevention & Immunity

A
  • Inactivated/recombinant vaccine (capsid protein)
  • No live vaccine!
  • Sow: protects from reproductional disorders, gives enough protection to piglets
  • Piglets: after weaning
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21
Q

PRDC: Porcine Respiratory Disease Complex

Most susceptible

A

4-7mo

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22
Q

PRDC: Porcine Respiratory Disease Complex

Clinical Signs

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A

*Slow growth
*Decreased feed conversion
*Fever, Lethargy
*Respiratory symptoms
(coughing, heavy breathing)

23
Q

PRDC: Porcine Respiratory Disease Complex

Pathology & Histopathology

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A

Interstitial Bronchopneumonia

Peribronchial fibrosis

24
Q

PRDC: Porcine Respiratory Disease Complex

Diagnosis

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A

CS, PM, ELISA, PCR, IF

25
PRDC: Porcine Respiratory Disease Complex Treatment
No effective treatment!
26
PRDC: Porcine Respiratory Disease Complex Prevention & Immunity
* Inactivated/recombinant vaccine (capsid protein) * No live vaccine! * Sow: protects from reproductional disorders, gives enough protection to piglets * Piglets: after weaning
27
PRF: Porcine Reproductive Failure Most susceptible
Pregnant sows
28
PRF: Porcine Reproductive Failure Target organs
Placental Crossing! | *Targets foetal myocardium, liver and macrophages
29
PRF: Porcine Reproductive Failure Clinical Signs
<70d: SMEDI | >70d: reproductive disorders, enlarged heart of fetus, abortion
30
PRF: Porcine Reproductive Failure Pathology
Foetal myocardiatis | Extensive fibrosis in the heart of foetus
31
PGE: Porcine Granulomatous Enteritis Most susceptible
1.5-2mo piglets
32
PGE: Porcine Granulomatous Enteritis Clinical Signs
Diarrhoea (initially yellow, later dark)
33
PGE: Porcine Granulomatous Enteritis Pathology
Microscopic granules in the intestines
34
PNL: Porcine Necrotising Lymphadenitis Most susceptible
Piglets FROM weaning
35
PNL: Porcine Necrotising Lymphadenitis Clinical Signs
Diarrhoea, Incoordination
36
PNL: Porcine Necrotising Lymphadenitis Pathology
Folliculair lymphoid necrosis
37
PCT: Porcine Congenital Tremor Most susceptible
Piglets UNTIL weaning
38
PCT: Porcine Congenital Tremor Clinical Signs
Shaking, Phtisis
39
PCT: Porcine Congenital Tremor Pathology
Demyelination
40
PEE: Porcine Exudative Epidermitis Most susceptible
5-35do piglets
41
PEE: Porcine Exudative Epidermitis Clinical Signs
Epidermitis
42
PEE: Porcine Exudative Epidermitis Pathology
Pyoderma
43
Acute Haemorrhagic Diarrhoea Clinical Signs
Vomiting, Diarrhoea, Lethargy, Vasculitis, | Thrombocytopaenia
44
Psittacine Beak and Feather Disease (PBFD) Most susceptible
Psittacine Birds (Also Goose, Duck, Pigeon, Ostrich, Canary) < 3yo
45
Psittacine Beak and Feather Disease (PBFD) Occurrence
Australia-> worldwide
46
Psittacine Beak and Feather Disease (PBFD) Spread
Contact with infected animal. feces, fomites, respiratory secretions * infected feather follicle * vertical via egg/sperm
47
Psittacine Beak and Feather Disease (PBFD) Pathogenesis
PO->intestine(respiratory)->viraemia-> all organs | Lymphoid organs especially
48
Psittacine Beak and Feather Disease (PBFD) Primary Replication
Intestine | Incubation: 7-10d
49
Psittacine Beak and Feather Disease (PBFD) Target Organs
All organs | *Lymphoid organs: *BM, Thymus, Bursa fabricii -> immunosupression
50
Psittacine Beak and Feather Disease (PBFD) Clinical Signs
< 3wo: Anaemia-Dermatitis Syndrome (anorexia, retarded growth and death), * dec. productivity, secondary infection *Secondary bacterial infection >3wo: no disease/mild immunosuppression
51
Psittacine Beak and Feather Disease (PBFD) Pathology & Histopathology
* Haemorrhages in gizzard and proventriculus * Atrophy of the thymus and Bursa Fabricii * Pale haemorrhagic tissues
52
Psittacine Beak and Feather Disease (PBFD) Diagnosis
CS, PM, lymphoid cultures, PCR
53
Psittacine Beak and Feather Disease (PBFD) Treatment
No effective treatment! | Ab
54
Psittacine Beak and Feather Disease (PBFD) Prevention and Immunity
Vaccine (live, attenuated) before laying period -> maternal immunity
Epidemiology
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