Papillomavirus
General Characteristics
- Linear dsDNA
- Icosahedral , no envelope
- Epitheliotropic, needs keratin for replication
- Oncogene
- Stenoxen
- hidden, latent infection
- Highly resistant
Bovine Papillomatosis
Most susceptible
All ages
Cutaneous warts usually < 2yo
Bovine Papillomatosis
Spread
- Direct contact with lesions
- Fly- mechanical Vector
- Iatrogenic route (needles )
Bovine Papillomatosis
Pathogenesis
shed from superficial cells,
- warts contain large amount of infectious virus
- proliferation of st. germanitivum - cauliflower like
- warts are benign, no viraemia
- heal without scaring
Bovine Papillomatosis
Primary Replication
Str. basale
Incubation: 1-2m
Bovine Papillomatosis
Target Organs
- BPV-1,2,3: all over the body
- BPV-4: intestine
- BPV-5,6: udder skin
- frequently different straints in the same animal
Bovine Papillomatosis
Clinical Signs
- Millet-sized, greyish, stuffed, non-painful nodules near *natural body orifices
- warts in udder-> inc. chance for mastitis
Bovine Papillomatosis
Pathology & Histopathology
Epithelial cell hyperplasia
Bovine Papillomatosis
Diagnosis
CS
virus cannot be isolated
PCR
histopathology
Bovine Papillomatosis
Treatment
- Surgical removal (cut/burn/freeze)
* Autovaccine
Bovine Papillomatosis
Prevention & Immunity
- Prevent injuries
* Disinfect skin
Equine Papillomatosis
Horses & donkeys
BPV-1,2
Target Organs
*Mainly head&neck
Dog Papillomatosis
Target Organs
- Young animals
* Oral& genital but can be generalized in immunosuppressed animals
Cat Papillomatosis
Target organs
- Young animals
* Oral& genital but can be generalized in immunosuppressed animals
