Coagulative Disorders

Question 1

Which conditions are classified under congenital coagulopathies? a. Von Willebrand disease b. Hemophilia A c. Hemophilia B d. All of the above

Answer 1

d

Question 2

Which of the following is NOT a congenital coagulopathy? a. Hemophilia C b. Von Willebrand disease c. Disseminated intravascular coagulation d. Hemophilia B

Answer 2

c

Question 3

Which congenital coagulopathy involves factor VIII deficiency? a. Hemophilia B b. Hemophilia A c. Hemophilia C d. Von Willebrand disease

Answer 3

b

Question 4

Hemophilia B is caused by deficiency of which factor? a. Factor VIII b. Factor XI c. Factor IX d. Factor VII

Answer 4

c

Question 5

Hemophilia C is associated with deficiency of which clotting factor? a. Factor XI b. Factor VIII c. Factor IX d. Factor X

Answer 5

a

Question 6

Which congenital coagulopathy is primarily a platelet adhesion disorder? a. Hemophilia A b. Hemophilia B c. Von Willebrand disease d. Hemophilia C

Answer 6

c

Question 7

Which type of vWD is characterized by reduced level of vWF? a. Type 2A b. Type 2B c. Type 1 d. Type 3

Answer 7

c

Question 8

Approximately what percentage of vWD patients have Type 1 vWD? a. 25% b. 50% c. 75% d. 100%

Answer 8

c

Question 9

Which vWD variant lacks intermediate and high molecular weight multimers? a. Type 1 b. Type 2A c. Type 2B d. Type 3

Answer 9

b

Question 10

Increased susceptibility to ADAMTS-13 cleavage is seen in which vWD type? a. Type 1 b. Type 2A c. Type 2M d. Type 3

Answer 10

b

Question 11

Which vWD variant is associated with a gain-of-function mutation in the A1 domain? a. Type 2A b. Type 2B c. Type 2M d. Platelet-type vWD

Answer 11

b

Question 12

Spontaneous binding to GP1b/IX/V complex on resting platelets occurs in which vWD type? a. Type 1 b. Type 2A c. Type 2B d. Type 3

Answer 12

c

Question 13

In which vWD type is platelet adhesion impaired due to unavailability of GP1b/IX/V? a. Type 2M b. Type 3 c. Type 2B d. Type 1

Answer 13

c

Question 14

Decreased platelet receptor binding is characteristic of which vWD variant? a. Type 1 b. Type 2A c. Type 2M d. Type 3

Answer 14

c

Question 15

Platelet-type vWD is also known as? a. Type 2M b. Type 3 vWD c. Pseudo-vWD d. Acquired vWD

Answer 15

c

Question 16

Platelet-type vWD is caused by molecular defect of which structure? a. vWF b. GP1b c. GPVI d. GPIIb/IIIa

Answer 16

b

Question 17

Complete quantitative defect of vWF is seen in which vWD type? a. Type 1 b. Type 2B c. Type 2M d. Type 3

Answer 17

d

Question 18

Which vWD variant is the most severe? a. Type 1 b. Type 2A c. Type 2B d. Type 3

Answer 18

d

Question 19

Which of the following is NOT a variant of vWD? a. Type 2A b. Type 2B c. Type 2M d. Type 4

Answer 19

d

Question 20

Decreased synthesis of clotting factors may result from which condition? a. Liver disease b. DIC c. Autoantibodies d. Mixing study error

Answer 20

a

Question 21

Production of abnormal clotting factor molecules results in which laboratory finding? a. Increased factor levels b. Decreased functional activity c. Increased platelet count d. Normal PT and aPTT

Answer 21

b

Question 22

Loss or consumption of clotting factors occurs in which condition? a. Hemophilia A b. DIC c. vWD d. Antiphospholipid syndrome

Answer 22

b

Question 23

Inactivation of clotting factors can be caused by? a. Inhibitors or antibodies b. Vitamin K excess c. Platelet dysfunction d. Increased synthesis

Answer 23

a

Question 24

Which is NOT a cause of low clotting factor levels in blood? a. Decreased synthesis b. Production of abnormal molecules c. Increased platelet adhesion d. Loss or consumption

Answer 24

c

Question 25

First-line replacement therapy for Hemophilia A is? a. Recombinant factor VIII concentrate b. Factor IX concentrate c. Fresh whole blood d. Platelet transfusion

Answer 25

a

Question 26

Which drug increases endogenous factor VIII and vWF release? a. EACA b. TXA c. Desmopressin d. Warfarin

Answer 26

c

Question 27

DDAVP is also known as? a. Recombinant FVIII b. 1-desamino-8-D-arginine vasopressin c. Tranexamic acid d. Eptifibatide

Answer 27

b

Question 28

Which of the following is an antifibrinolytic used in Hemophilia A? a. Aspirin b. TXA c. Heparin d. Abciximab

Answer 28

b

Question 29

EACA is classified as which type of agent? a. Anticoagulant b. Antiplatelet c. Antifibrinolytic d. Thrombolytic

Answer 29

c

Question 30

Which is a human plasma-derived factor VIII concentrate? a. Wilate b. Clopidogrel c. Dipyridamole d. Ticagrelor

Answer 30

a

Question 31

All are plasma-derived factor VIII concentrates EXCEPT? a. Alphanate b. Humate-P c. Wilate d. Recombinant FVIII

Answer 31

d

Question 32

Factor VIII inhibitors are usually which antibody subtype? a. IgG1 b. IgG2 c. IgG3 d. IgG4

Answer 32

d

Question 33

Presence of factor VIII inhibitor is suggested when factor VIII activity is? a. > 80% b. 50–80% c. < 30% d. Normal

Answer 33

c

Question 34

Detection of factor VIII inhibitors requires which test condition? a. Immediate mixing study b. Prolonged incubation at 37°C c. Cold incubation d. Platelet aggregation study

Answer 34

b

Question 35

The assay used to quantify factor VIII inhibitors is? a. PT assay b. aPTT assay c. Bethesda assay d. Mixing correction index

Answer 35

c

Question 36

One Bethesda unit is defined as? a. 100% neutralization of factor VIII b. 75% neutralization c. 50% neutralization d. 25% neutralization

Answer 36

c

Question 37

Autoantibodies against factor VIII:C are detected using which assay? a. PT b. aPTT c. Bethesda assay d. D-dimer

Answer 37

c

Question 38

Antibodies may develop against all of the following factors EXCEPT? a. Factor V b. Factor II c. Factor XIII d. Factor XI

Answer 38

c

Question 39

Post-transfusion inhibitors are classified under which category? a. Congenital inhibitors b. Specific circulating anticoagulants c. Lupus anticoagulants d. Antiplatelet antibodies

Answer 39

b

Question 40

Lupus anticoagulants belong to which inhibitor group? a. Specific inhibitors b. Non-specific inhibitors c. Factor VIII inhibitors d. Platelet inhibitors

Answer 40

b

Question 41

Antiphospholipid antibody syndrome is most commonly associated with? a. Bleeding only b. Venous and arterial thrombosis c. Thrombocytopenia only d. Factor VIII deficiency

Answer 41

b

Question 42

ACA and LA’s are associated with which condition? a. Hemophilia A b. Antiphospholipid antibody syndrome c. vWD Type 3 d. Afibrinogenemia

Answer 42

b

Question 43

Lupus anticoagulants may be present in which conditions? a. Primary only b. Secondary only c. Primary and secondary d. Congenital only

Answer 43

c

Question 44

Which is NOT a specific circulating anticoagulant inhibitor? a. Factor VIII inhibitor b. Factor V inhibitor c. Lupus anticoagulant d. Factor X inhibitor

Answer 44

c