RBC Membrane Problems

Question 1

Paroxysmal Nocturnal Hemoglobinuria (PNH) is? a. hereditary b. congenital c. acquired d. autoimmune only

Answer 1

c

Question 2

Paroxysmal Nocturnal Hemoglobinuria (PNH) is due to? a. ankyrin defect b. spectrin defect c. band 3 defect d. GPI anchor deficiency (protein)

Answer 2

d

Question 3

Hereditary Spherocytosis (HS) defects in? a. ankyrin b. spectrin c. band 3 d. protein 4.2

Answer 3

a b c d

Question 4

Hereditary Spherocytosis (HS) forms? a. elliptocytes b. stomatocytes c. target cells d. spherocytes

Answer 4

d

Question 5

Hereditary Elliptocytosis (HE) defects in? a. spectrin b. protein 4.1 c. actin d. adducin

Answer 5

a b c d

Question 6

Hereditary Elliptocytosis (HE) forms? a. elliptocytes b. spherocytes c. acanthocytes d. target cells

Answer 6

a

Question 7

Rh null Syndrome is due to? a. GPI anchor deficiency b. glycophorin (A B) defects c. cholesterol defects d. absence of all Rh antigens

Answer 7

d

Question 8

Rh null Syndrome leads to? a. aplastic anemia b. hemolytic anemia c. megaloblastic anemia d. polycythemia vera

Answer 8

b

Question 9

Rh null Syndrome forms? a. stomatocytes b. target cells c. elliptocytes d. spherocytes

Answer 9

a b

Question 10

Rh null Syndrome forms stomatocytes and target cells due to? a. decreased RBC production b. increased destruction of RBCs c. decreased hemoglobin synthesis d. increased iron

Answer 10

b

Question 11

Glycophorin (A B) defects cause? a. severe hemolytic anemia b. mostly mild RBC shape changes c. acanthocyte formation d. spherocyte formation

Answer 11

b

Question 12

Glycophorin (A B) defects cause altered malarial susceptibility with? a. increased susceptibility to P. falciparum b. resistance to P. falciparum c. resistance to P. vivax d. no change

Answer 12

b

Question 13

Cholesterol defects lead to? a. spherocyte formation b. elliptocyte formation c. stomatocyte formation d. acanthocyte formation

Answer 13

d

Question 14

Cholesterol defects causing acanthocytes involve? a. high levels only b. low levels only c. high or low levels d. normal levels

Answer 14

c

Question 15

Cholesterol defects cause acanthocyte formation because cholesterol is part of the? a. RBC nucleus b. RBC membrane c. hemoglobin d. plasma proteins

Answer 15

b