2 MTAP: Hematology > Platelet Disorders > Flashcards

Platelet Disorders Flashcards

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1
Q

Thrombocytosis is classified under which platelet disorder? a. Qualitative b. Quantitative c. Functional d. Distributional

A

b

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2
Q

Which condition belongs to reactive thrombocytosis? a. Polycythemia vera b. Chronic myelogenous leukemia c. Blood loss and surgery d. Essential thrombocythemia

A

c

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3
Q

Splenectomy may result in which platelet disorder? a. Thrombocytopenia b. Reactive thrombocytosis c. Immune destruction d. Abnormal distribution

A

b

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4
Q

Iron deficiency anemia is associated with which condition? a. Reactive thrombocytosis b. Myelofibrosis c. DIC d. TTP

A

a

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5
Q

Which is NOT a cause of reactive thrombocytosis? a. Stress and exercise b. Inflammation and disease c. Rebound thrombocytosis d. Essential thrombocythemia

A

d

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6
Q

Which disorder is classified under myeloproliferative disorders? a. Fanconi anemia b. Polycythemia vera c. Wiskott-Aldrich syndrome d. TAR syndrome

A

b

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7
Q

Pancytosis is seen in which disorder? a. Thrombocythemia b. Polycythemia vera c. Myelofibrosis with myeloid metaplasia d. Chronic myelogenous leukemia

A

b

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8
Q

Which is NOT a myeloproliferative disorder? a. Chronic myelogenous leukemia b. Essential thrombocythemia c. Myelofibrosis with myeloid metaplasia d. Iron deficiency anemia

A

d

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9
Q

Platelet count of 1

A

000 × 10⁹/L is seen in which condition? a. Reactive thrombocytosis b. Essential thrombocythemia c. Immune thrombocytopenia d. DIC

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10
Q

Essential thrombocythemia is indicative of which disease group? a. Congenital thrombocytopenia b. Myeloproliferative disease c. Immune destruction d. Abnormal distribution

A

b

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11
Q

Reference value of platelet count is? a. 100

A

000–300

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12
Q

Which complication may occur in essential thrombocythemia? a. Anemia b. Thrombosis c. Leukopenia d. Neutropenia

A

b

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13
Q

Increased thromboxane β2 is associated with? a. Reactive thrombocytosis b. Essential thrombocythemia c. ITP d. DIC

A

b

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14
Q

Hemorrhage in essential thrombocythemia is due to? a. Increased ADP synthesis b. Increased epinephrine response c. Lack of epinephrine response d. Increased platelet adhesion

A

c

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15
Q

Lack or decreased synthesis of ADP is seen in? a. Reactive thrombocytosis b. Essential thrombocythemia c. TTP d. HUS

A

b

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16
Q

Thrombocytopenia is classified as which platelet disorder? a. Quantitative b. Qualitative c. Functional d. Distributional

A

a

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17
Q

Which is a cause of impaired or decreased platelet production? a. Acute ITP b. May-Hegglin anomaly c. DIC d. TTP

A

b

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18
Q

Which disorder is congenital and associated with thrombocytopenia? a. Bernard-Soulier syndrome b. DIC c. HIV infection d. Pregnancy

A

a

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19
Q

Which is NOT a congenital cause of impaired platelet production? a. Fanconi anemia b. Wiskott-Aldrich syndrome c. TAR syndrome d. Heparin-induced thrombocytopenia

A

d

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20
Q

Autosomal and X-linked thrombocytopenia belongs to which category? a. Increased destruction b. Impaired production c. Abnormal distribution d. Dilutional loss

A

b

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21
Q

Neonatal thrombocytopenia is classified under which mechanism? a. Acquired b. Congenital c. Impaired production d. Immune destruction

A

c

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22
Q

Viral infection causes which type of thrombocytopenia? a. Congenital b. Neonatal c. Acquired d. Distributional

A

c

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23
Q

Drug-induced decreased platelet production is classified as? a. Immune destruction b. Acquired impaired production c. Non-immune destruction d. Dilutional loss

A

b

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24
Q

Acute and chronic ITP belongs to which category? a. Non-immune destruction b. Immune platelet destruction c. Impaired production d. Abnormal distribution

A

b

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25
Heparin-induced thrombocytopenia is classified as? a. Non-immune destruction b. Immune drug-induced c. Congenital disorder d. Dilutional loss
b
26
Neonatal isoimmune thrombocytopenia is due to? a. Platelet sequestration b. Antibodies against platelets c. Decreased synthesis d. Platelet dilution
b
27
Which is NOT an immune cause of increased platelet destruction? a. Acute ITP b. Chronic ITP c. TTP d. Posttransfusion isoimmune thrombocytopenia
c
28
Thrombocytopenia in pregnancy belongs to which category? a. Immune destruction b. Non-immune destruction c. Impaired production d. Abnormal distribution
b
29
Which condition is classified as non-immune thrombocytopenia? a. Acute ITP b. Secondary autoimmune thrombocytopenia c. DIC d. Neonatal autoimmune thrombocytopenia
c
30
TTP DIC and HUS are classified under? a. Impaired production b. Immune destruction c. Non-immune destruction d. Distributional disorders
c
31
Splenic sequestration causes thrombocytopenia due to? a. Increased destruction b. Decreased production c. Abnormal distribution d. Dilutional loss
c
32
In normal distribution what percentage of platelets are sequestered in the spleen? a. 20% b. 30% c. 50% d. 70%
b
33
Splenomegaly results in which platelet abnormality? a. Increased platelet production b. Increased platelet destruction c. Increased platelet sequestration d. Platelet dilution
c
34
Kasabach-Merritt syndrome causes thrombocytopenia due to? a. Immune destruction b. Platelet sequestration to a tumor c. Decreased synthesis d. Drug-induced loss
b
35
Hypothermia causes thrombocytopenia by which mechanism? a. Immune destruction b. Impaired production c. Abnormal distribution d. Increased synthesis
c
36
Massive transfusion causes thrombocytopenia due to? a. Splenic sequestration b. Platelet loss c. Immune destruction d. Congenital defect
b
37
Extracorporeal circulation results in thrombocytopenia due to? a. Platelet loss b. Immune destruction c. Impaired production d. Increased aggregation
a
38
In abnormal distribution platelets are sequestered? a. In the bone marrow b. Outside the blood vessels c. Inside platelets d. In circulation only
b
39
Chemotherapeutic agents cause which type of thrombocytopenia? a. Immune b. Non-immune c. Acquired decreased production d. Abnormal distribution
c
40
Which drug affects platelet production? a. Methotrexate b. Heparin c. Aspirin d. Warfarin
a
41
Busulfan is classified under? a. Anticonvulsants b. Chemotherapeutic agents c. Antibacterial agents d. Tranquilizers
b
42
Which drug is a cytotoxic agent affecting platelet production? a. Cisplatin b. Digoxin c. Sulfonamides d. Estrogen
a
43
Cytosine arabinoside belongs to which group? a. Antibacterial agents b. Chemotherapeutic agents c. Tranquilizers d. Anticonvulsants
b
44
Long term ingestion of ethanol causes thrombocytopenia by? a. Immune destruction b. Increased sequestration c. Decreased production d. Dilution
c
45
Large dose of estrogen or estrogenic drugs may cause? a. Immune thrombocytopenia b. Acquired thrombocytopenia c. Congenital thrombocytopenia d. Distributional defect
b
46
Diethylstilbestrol is an example of? a. Antibacterial agent b. Estrogenic drug c. Chemotherapeutic agent d. Anticonvulsant
b
47
Chloramphenicol causes thrombocytopenia by? a. Immune destruction b. Decreased platelet production c. Increased sequestration d. Platelet dilution
b
48
Which is NOT listed as a drug affecting platelet production? a. Anticonvulsants b. Tranquilizers c. Antibacterial agents d. Heparin
d
49
Immune thrombocytopenic purpura is characterized by? a. Platelet trauma b. Autoantibody against platelets c. Decreased thrombopoietin d. Platelet dilution
b
50
Acute ITP commonly occurs in? a. Older people b. Younger ages c. Neonates d. Pregnant women
b
51
Petechiae and mucosal bleeding are seen in? a. Chronic ITP b. Acute ITP c. DIC d. HUS
b
52
Epistaxis in acute ITP is classified as? a. Mucosal bleeding b. Internal bleeding c. Surgical bleeding d. Renal bleeding
a
53
Chronic ITP is more common in? a. Children b. Neonates c. Older people d. Adolescents
c
54
Menorrhagia is a feature of? a. Acute ITP b. Chronic ITP c. HIT d. DIC
b
55
Recurrent epistaxis and easy bruising are seen in? a. Acute ITP b. Chronic ITP c. TTP d. HUS
b
56
Chronic ITP involves autoantibodies against? a. GpIb b. GpIIb and IIIa c. Factor VIII d. Fibrinogen
b
57
Which glycoprotein is also targeted in chronic ITP? a. GpIa/IIa b. GpV c. GpIX d. GpIb
a
58
Immunoglobulin involved in chronic ITP is? a. IgA b. IgM c. IgG d. IgE
c
59
Hapten-induced antibodies are seen in? a. HIT b. Drug-induced thrombocytopenia c. Post transfusion purpura d. Acute ITP
b
60
Drug-dependent antibodies cause? a. Immune-complex thrombocytopenia b. Drug-induced thrombocytopenia c. Non-immune destruction d. Decreased production
b
61
Which is NOT a mechanism of drug-induced thrombocytopenia? a. Hapten-induced antibodies b. Drug-dependent antibodies c. Drug-induced autoantibodies d. Platelet sequestration
d
62
Heparin-induced thrombocytopenia is due to? a. Platelet trauma b. Excess heparin infusion c. Decreased production d. Splenic sequestration
b
63
HIT is mediated by? a. Autoantibodies b. Immune-complexes induced c. Mechanical destruction d. Dilution
b
64
HIT has how many types? a. One b. Two c. Three d. Four
b
65
A >30% decrease in platelet count from baseline may indicate? a. Acute ITP b. HIT c. DIC d. TTP
b
66
ELISA is used as which laboratory test? a. Platelet function test b. Antigen test for HIT c. Coagulation factor assay d. Bleeding time
b
67
Which is a laboratory test for HIT? a. ELISA b. PT c. aPTT d. Bleeding time
a
68
Post transfusion purpura occurs after receiving? a. Plasma only b. Platelet containing blood products c. Cryoprecipitate d. Albumin
b
69
Antibody against platelet antigen in PTP includes? a. GpIIb/IIIa b. P1A1 (HPA-1a) c. ADAMTS-13 d. vWF
b
70
Which is NOT listed as a platelet antigen in PTP? a. Baka b. Yuk c. Bra d. GpIb
d
71
Post transfusion purpura is generally self limiting and recovers after? a. 7 days b. 14 days c. 21 days d. 30 days
c
72
Mortality rate in PTP is reported as? a. 1–5% b. 5–10% c. 10–15% d. 20–25%
c
73
Platelet refractoriness is defined as? a. Increased platelet count b. Low platelet uncorrected despite transfusion c. Autoimmune platelet destruction d. Decreased platelet synthesis
b
74
Platelet refractoriness is commonly caused by? a. Same donor platelets b. Different donor platelet concentrates c. Iron deficiency d. Splenomegaly
b
75
Treatment of platelet refractoriness is? a. Steroids b. IVIG c. Single donor platelet apheresis d. Splenectomy
c
76
Microangiopathic syndromes cause thrombocytopenia due to? a. Immune destruction b. Platelet trauma c. Decreased production d. Dilution
b
77
Multiple clots causing turbulence are seen in? a. Immune thrombocytopenia b. Microangiopathic syndromes c. Drug-induced thrombocytopenia d. HIT
b
78
Lack of ADAMTS-13 is seen in? a. DIC b. HUS c. TTP d. HIT
c
79
ADAMTS-13 is classified as? a. Clotting factor b. Metalloprotease with thrombospondin motif c. Platelet receptor d. Coagulation inhibitor
b
80
Escherichia coli O157-H7 is associated with? a. TTP b. DIC c. HUS d. HIT
c
81
Shiga like toxin damages which organ in HUS? a. Liver b. Lung c. Renal vessels d. Brain
c
82
DIC activates clotting secondary to? a. Autoimmunity b. Trauma infection or disease c. Platelet antibodies d. Estrogen
b
83
Schistocytes are seen in? a. Immune thrombocytopenia b. Microangiopathic syndromes c. Essential thrombocythemia d. HIT
b
84
Mechanical destruction of platelets occurs due to? a. Autoantibodies b. Obstructed blood vessels c. Decreased synthesis d. Drug toxicity
b
85
HELLP syndrome causes thrombocytopenia by? a. Decreased production b. Increased destruction c. Immune destruction d. Dilution
b
86
Gestational thrombocytopenia is classified under? a. Increased platelet destruction b. Decreased platelet production c. Immune thrombocytopenia d. Congenital disorders
a
87
Increased platelet sequestration occurs due to? a. Splenomegaly b. Autoantibodies c. Platelet dilution d. Decreased synthesis
a
88
Kasabach-Merritt syndrome causes thrombocytopenia due to? a. Immune destruction b. Sequestration to a tumor c. Decreased production d. Dilution
b
89
Glanzmann thrombasthenia affects which platelet function? a. Adhesion b. Aggregation c. Secretion d. Phospholipid membrane
b
90
Bernard-Soulier syndrome affects? a. Aggregation b. Adhesion c. Secretion d. Phospholipid changes
b
91
Storage pool disease is a defect of? a. Aggregation b. Adhesion c. Secretion d. Membrane phospholipid
c
92
Cyclooxygenase deficiency causes which qualitative defect? a. Aggregation b. Secretion c. Adhesion d. Distribution
b
93
Scott syndrome is a disorder of? a. Aggregation b. Adhesion c. Secretion d. Membrane phospholipid
d
2 MTAP: Hematology
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