Commercial applications

Question 1

Describe the first transgenic fish

Answer 1

1985
Goldfish expressing human GH
Direct injection into the egg cytoplasm

Question 2

Describe Canadian salmon

Answer 2

AFP (antifreeze protein) added to salmon to allow them to grow in all seasons in Canadian cold waters

Question 3

Describe AquAdvantage salmon

Answer 3

GH
Growth rate affected rather than the final size
Less food required and reach market size 1 year earlier

Question 4

Describe how human drugs can be made in sheep milk

Answer 4

AAT (antitrypsin) is treatment for cystic fibrosis
PI of AAT coupled with sheep β-lactoglobulin promoter which is tissue-specific to the mammary glands
Protein made in milk