Compounding Agents

Question 1

Adsorbents

2 common ones

Answer 1

Used to keep powders dry

1. Mg oxide/carbonate
2. Koalin

Question 2

Antifoaming agents

Answer 2

Breaks up and inhibits the formation of foam

1. Simethicone

Question 3

Antioxidants

Answer 3

Prevents Oxidation

• Ascorbic acid

Question 4

Binders

Answer 4

Adhesive materials that holds powders together

• Acacia
• Starch paste

Question 5

Coatings

Answer 5

Prevent degradation to light and anything else

• Shelac, gellatin, gluten

Question 6

Diluents (fillers) 7

Answer 6

Add size

1. White lactose
2. Startches
3. Calcium salts
4. lactose
5. mannitol
6. Sorbitol
7. cellulose

Question 7

Disintegrant 5

Answer 7

1. Alginic acid
2. Polacrilin potassium (Amberlite)
3. Cellulose products
4. Starches
5. Nu-tab

Question 8

Emolients

Answer 8

Softens or smoothes the skin

1. Petroleum Jelly

Question 9

Enteric coatings

Answer 9

• Cellulose acetate phthalate
• SHellac

Question 10

Flavoring

Answer 10

• Sugar free, artificial: aspartame, saccharin
• Glycerin
• Dextrose
• Lactose
• Mannitol
• Sorbitol
• phenylalanine
• stevia
• Xylitol

Question 11

Gelling thickening agents

Answer 11

• Agar
• Alginate
• various gums
• acacia
• Natural gums (gelatin, tragacanth, bentonite)
• Carbomer
• cellulose
• starches

Question 12

Glidant

Answer 12

Improves flow

• Colloidal silica
• mg stearate

Question 13

Hydrophilic solvents

Answer 13

PEG, Alcohol

Question 14

Hydrophobic solvents

Answer 14

• Oils: borage, canola
• Fats: Omega 3

Question 15

Levigating Agents

Answer 15

• Liquid used when reducing particle size
• Mineral oil
• Glycerin

Question 16

Lubricant- Antiadherent

Answer 16

Keeps from sticking together

• Mg stearate
• Calcium
• mineral oil

Question 17

Preservatives

Answer 17

• Chlorhexidine
• Ophthalmics:
  
  • EDTA, sodium benzoate, benzoic acid
  • benzalkonium chloride
  • thimerosal

Question 18

Suppository base

Answer 18

• Cocoa butter, hydrogenate vegetable oil (palm, palm kernel, coconute oil, PEG, glycerinated gelatin

Question 19

Uses of PEG 7

Answer 19

• Suppository base
• surfactant
• solvent
• plasticizer
• ointment base
• lubricant
• troche base

Question 20

ISO Air Quality In the PEC

Answer 20

• Compounded Sterile products are made inside a hood or isolator which is the PEC
• Must be ISO 5
• Clean PEC before each shift, before and after batches, every 30 minutes and whenever it needs to including after spills
• Clean with sterile IPA 70% and sterile lent free wipes

Question 21

Hazardous drugs can be? 5 things

Answer 21

1. Carcinogenic
2. Teratogenic
3. Reproductive toxicity
4. Cause organ toxicity at low doses
5. Genotoxic cause DNA damage and cancer

Question 22

Drugs that require special handling to avoid toxicity

4 groups hazardous

Answer 22

1. Antineoplastic
2. Drugs with reporductive risk
   
   1. Category X
   2. D and Cs
   3. Paroxetine
   4. Methotrexate
   5. misoprostol
   6. mifepristine
   7. ribavirin
   8. 5-alpha reducase (dutasterde, finasteride)
3. Hormones
   
   1. Contraceptives
   2. Estradiol
   3. Testosterone
4. Transplant drugs
   
   1. Mycophenolate
   2. Tacrolimus
   3. cyclosporine
   4. everlimus
   5. sirolimus
5. Others:
   
   1. Colchine, dronedarone, fluconazole, spironolacotne, risperidone, raloxifene, rasagiline, ziprasidone

Question 23

Hazardous drug spills

Answer 23

• Spill kits
• Person exposed
  
  • Remove contaminated garments
  • Wash exposed area
  • flush eyes if exposed
  • Send for emergency med evaluation