Cytotoxic Agents

Question 1

What are the main/generic S/E of cytotoxic agents?

Answer 1

• Gout
• Alopecia
• Deafness
• Normoblastic Anaemia
• Pancytopenia

Question 2

Name an alkylating agent.

Answer 2

Cyclophosphamide

Question 3

What are the adverse effects of cyclophosphamide?

Answer 3

• Haemorrhagic cystitis
• Myelosuppression
• TCC

Question 4

Name 2 cytotoxic antibiotics.

Answer 4

Bleomycin

Doxorubicin

Question 5

What is the mmain side effect of bleomycin?

Answer 5

Lung fibrosis

Question 6

What is the main side effect of doxorubicin?

Answer 6

Cardiomyopathy

Question 7

Name 4 antimetabolite cytotoxic agents.

Answer 7

• Methotrexate
• 5-Fluorouracil
• 6-Mercaptopurine
• Cytarabine

Question 8

What side effect do all antimetabolite cytotoxic agents have in common?

Answer 8

Myelosuppression

Question 9

What are the adverse effects of methotrexate?

Answer 9

• Myelosuppression
• Mucositis
• Liver fibrosis
• Lung fibrosis

Question 10

What are the adverse effects of Fluorouracil?

Answer 10

• Myelosuppression
• Mucositis
• Dermatitis

Question 11

What is the main S/E of 6-mercaptopurine?

Answer 11

Myelosuppression

Question 12

What are the adverse effects of cytarabine?

Answer 12

• Myelosuppression
• Ataxia

Question 13

Name 2 cytotoxic agents that act on microtubules.

Answer 13

Vinicristine

Docetaxel

Question 14

What are the adverse effects of Vinicristine?

Answer 14

• Peripheral neuropathy (reversible)
• Paralytic ileus

Question 15

What are some S/E of Docetaxel?

Answer 15

Neutropenia

Question 16

Two other cytotoxic agents are Cisplatin and Hydroxyurea.

What are their main side effects?

Answer 16

• Cisplatin - Ototoxicity, Peripheral neuropathy, hypomagnesaemia.
• Hydroxyurea - myelosuppression