DOACs

Question 1

What is the UK brand name of dabigratran?

Answer 1

Pradaxa

Question 2

What is the UK brand name of Rivaroxaban?

Answer 2

Xarelto

Question 3

What is the UK brand name of apixaban?

Answer 3

Eliquis

Question 4

What is the mechanism of action of dabigatran?

Answer 4

Direct thrombin inhibitor

Question 5

What is the MOA of Rivaroxaban?

Answer 5

Direct factor Xa inhibitor

Question 6

What is the MOA of Apixaban?

Answer 6

Direct factor Xa inhibitor

Question 7

How id dabigatran excreted?

Answer 7

Mostly renal

Question 8

How is rivaroxaban exreted?

Answer 8

Mostly Liver

Question 9

How is apixaban exreted?

Answer 9

Mostly faecal

Question 10

What are the NICE indications of treatment using dabigatran?

Answer 10

• Prevention of VTE following hip/knee surgery
• Prevention of stroke in non-valvular AF with co-morbidities:
  
  • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.

Question 11

What are the NICE indications of treatment using Rivaroxaban?

Answer 11

1. Prevention of VTE following hip/knee surgery
2. Treatment of DVT and PE
3. Prevention of stroke in non-valvular AF with co-morbidities:
   
   • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.

Question 12

What are the NICE indications of treatment using Apixaban?

Answer 12

1. Prevention of VTE following hip/knee surgery
2. Prevention of stroke in non-valvular AF with co-morbidities:
   
   • Prior stroke or TIA, Age >=75 years, HTN, DM, HF.

Question 13

Describe the coagulation cascade & where oral anticoagulants fit in it?

Answer 13

Question 14

What is considered to be the safer DOAC?

Answer 14

Apixaban (but probably due to the short half life)

Question 15

What eGFR is Dabigatran not recommended in?

Answer 15

<30ml/min

Question 16

What eGFR are Rivaroxaban or Apixaban not recommended in?

Answer 16

<15

Question 17

What condition is dabigatran contra-indicated in?

Answer 17

Mechanical & prosthetic heart valves.

Higher chance of bleeding and thrombotic events.

Question 18

What is the only DOAC that can be used to treat VTE or PE?

Answer 18

Rivaroxaban.