Bullae/blisters + mucosal involvement.
Antibodies against?
Management?
Pemphigus vulgaris
Desmoglein 3.
Steroids > immunosuppression
Blisters/bullae and no mucosal involvement
Antibodies?
Bullous pemphigoid
Antibodies against hemidesmosomal proteins BP180 and BP230
Causes of acanthuses nigricans?
GI adenocarcinoma
Insulin resistance
Acromegaly
Cushings
OCP
Hypothyroid
What malignancy’s are associated with dermatomyositis?
Lung, breast and ovarian
Port wine stain + ocular manifestations+ epilepsy
Sturge- weber syndrome
Most aggressive melanoma
Nodular
Psoariasis management
Potent steroid OD + vit D analogue OD for 4 weeks
Vit D analogue BD if no improvement
Potent steroid BD or coal tar if no improvement after 8-12 weeks
Phototherapy
Systemic therapy/biologics
Rash does no spare nasolabial folds?
Rosacea
Which antibiotic can cause irreversible skin pigmentation?
Minocycline
Drugs that cause SJS
Co-trim
Penicillins
Sulphonamides
Lamotrigine, carbamazepine, phenytoin
Allopurinol
NSAIDS
OCP
Systemic mastocytosis
- Features
- Diagnosis
Urticaria pigmentosa (urticaria on rubbing), flushing, abdo pain
Elevated tryptase
Urinary histamine
Bone marrow testing for definitive diagnosis
Type of hypersensitivity reaction that causes itch with scabies.
Treatment of scabies
Type IV (delayed)
Permethrin (5%)
Malathion (0.5%)
Eczema herpeticum
- Presentation
- Causes
- Treatment
Monomorphic punched-out erosions, painful, unwell
- HSV 1/2 and coxsackie
- IV aciclovir
Treatment of squamous cell cancer
Excision with 4mm margins if <20mm
6mm markings if >20mm
Mohs surgery if high risk or cosmetic area
% of body affected in SJS and TENs
<10% in SJS
> 30% in TENs
Management of rosacea
flushing only - topical brimonidine
Papules - topical ivermectin/metronidazole/axelic acid
Mod-severe papules - Topical ivermectin and oral doxy
Lichen Plans treatment
Topical steroids
Mild topical steroid
Hydrocortisone 0.5-2.5%
Moderate topical steroid
Betamethasone valerate 0.025% (Betnovate)
Clobetasone butyrate 0.05% (Eumovate)
Potent topical steroids
Fluticasone propionate 0.05% (Cutivate)
Betamethasone valerate 0.1% (Betnovate)
Very potent topical steroid
Clobetasol propionate 0.05% (Dermovate)
Drug causes of EN
Penicillins
Sulphonamides
COCP
Conditions assoc with koebner phenomenon
Psoriasis
Vitiligo
Warts
Lichen planus
Lichen sclerosis
Molluscum
Effect of phenytoin on hair
Cn cause hirsutism
