MRCP Part 1 > Science > Flashcards

Science Flashcards

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1
Q

What is TNF Alpha and what secretes it?

A

Pro inflam cytokine:
- activates macrophages & neut
- responds to gram -ve bacteria
- T-cell activation
- anti tumour effects

Secreted by macrophages

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2
Q

What does TNF alpha bind to?

A

p55 and p75 causing apoptosis

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3
Q

List some TNF alpha inhibitors

A

Infliximab
Etanercept
Adalimumab
Golimumab

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4
Q

Adverse effects of TNF alpha inhibitors?

A

Reactivation of latent TB

Demyelination

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5
Q
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