What is diffusion ? and key points
net movement of molecules/ions from an area of high conc to an area of low conc continuing until equilibrium is reached.
key points
Movement occurs down the concentration gradient (not along).
Although the overall direction is from high to low concentration, individual particle movement is random.
No membrane is needed for diffusion to occur—it can happen in air or liquid.
What type of process is diffusion ?
passive process - not require energy
What can pass through the membrane ?
and what cannot diffuse easily ?
small uncharged molecules ( small
Non-polar
Lipid-soluble molecules (e.g. oxygen, carbon dioxide, steroid hormones)
cannot
Charged ions (e.g. Na⁺, Cl⁻)
Large molecules (e.g. glucose)
Water-soluble or polar molecules
factors affecting diffusion
higher temp = particles have more kinetic energy -> leads to faster movement and faster diffusion
factors affecting diffusion
Concentration Gradient: The greater the difference in concentration between two areas, the faster the rate of diffusion.
Thinner membranes = shorter distance for molecules to travel.
Results in a faster rate of diffusion.
Define facilitated diffusion
net movement of molecule from high conc to low conc through the membrane and though a integral protein molecule
( passive process )
What is facilitated diffusion ?
Facilitated diffusion helps large, polar, or charged molecules pass through the membrane with the help of proteins.
Still passive – no energy required
Still down a concentration gradient
Types of Transport Proteins
Channel Proteins
Form pores or tunnels in the membrane.
Allow specific charged particles to pass (e.g. Na⁺, Cl⁻).
Some are always open; others are gated:
Ligand-gated (opened by molecule binding)
Voltage-gated (opened by changes in membrane potential)
Pressure-gated
Types of Transport Proteins
Example:
Aquaporins – channel proteins that allow water to pass more efficiently across the membrane.
Carrier Proteins
Bind to a specific molecule.
Undergo a shape change to transport the molecule across the membrane.
Used for large molecules (e.g. glucose, amino acids).
Slower than channel proteins due to shape change.
pure water has the ——– water potential of ————.
Adding solute to the solvent —————- the water potential of the solution
highest , 0 KPA
increases
Types of Transport Proteins
Example:
Aquaporins – channel proteins that allow water to pass more efficiently across the membrane.
Carrier Proteins
Bind to a specific molecule.
Undergo a shape change to transport the molecule across the membrane.
Used for large molecules (e.g. glucose, amino acids).
Slower than channel proteins due to shape change.
If two aqueous solutions are separated by a partially permeable membrane, water molecules will move from the solution with the ——- water potential to the ..
highest, solution with the lowest water potential
osmosis will cease when
water potential on both sides of the membrane becomes equal
Factors Affecting Facilitated Diffusion
✅ Factors That Increase Rate:
Steep concentration gradient
Increased number of channel/carrier proteins
Limiting Factors:
Protein saturation: Once all proteins are in use, increasing concentration further has no effect.
Protein availability: More transport proteins = faster rate (up to saturation).
Graph Explanation:
Facilitated diffusion starts faster than simple diffusion.
Eventually, it plateaus ( no change) due to all proteins being occupied.
This point is called the saturation point or limiting factor.