Define cell
smallest unit of a living organism
Define tissue
Group of similar cells that perform an overall function
Define organ
several different tissues to perform an overall function
Define organ system
Group of organs to form a larger function
What’s a basement membrane ?
a specialised thin non-cellular layer of extracellular matrix. it sits between epithelial or endothelial cells and the underlying connective tissue, separating out the layer
composition of basement membrane
collagen, laminin ( a structural glycoprotein ) proteoglycans
function of basement membrane
support provides structural support and other proteins to overlying cells and tissues
selective barrier - acts as a
selective filter , controlling the movement of molecules between epithelial layer and underlaying tissue. for example in the kidney, the glomerular basement membrane prevents large proteins.
cell signalling plays a role in
cell influencing cell behaviour , migration differentiation
- tissue repair and regeneration
Whys blood considered a connective tissue ?
connects diff parts of the body transporting things between them. ( co2. o2 haeomoglobin )
What makes blood unique compared to other tissues ?
because of its fluid extracellular matrix
- plasma entirely liquid
use of tissues in research and development
scientists use animals and isolated tissues for study
- development and disease in lab
- drug discovery and development in industry
- gene and cell therapies
- tissue engineering
types of animal tissues used in vitro
whole animals
isolated organs
tissue culture
stem cell cultures
organoids