Dobutamine

Question 1

Brand Name

Answer 1

Dobutrex

Question 2

Indications / Uses

Answer 2

Low CO
- (CHF. Cardiogenic shock, sepsis induced myocardial dysfunction)
Symptomatic brady unresponsive to atropine and pacing
Dilated cardiomyopathy
Increased LV filling pressures
Dobutamine stress EKG test
Tx of depressed myocardial contractility in sepsis pts

Question 3

Chemical structural considerations

Answer 3

Synthetic catecholamine mixture of 2 isomers

Question 4

MOA

Answer 4

nonselective Beta agonist with greater selectivity for B1 receptors
- Increased Contractility, CO, CI
- Decreased PVR, LV filling pressure (preload), increased coronary blood flow

Question 5

Adverse effects

Answer 5

Dysrrhythmia > Hypotension

Question 6

Dosing

Answer 6

2-20 mcg/kg/min

Question 7

Vial concentration

Answer 7

20 mL/ 250 mg