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Ibuprofen Flashcards

(25 cards)

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1
Q

Brand Name

A

Caldolor

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2
Q

Broad Category

A

Analgesic / Antipyretic / NSAID

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3
Q

Pharm Class

A

Proprionic acid derivative
Nonselective COX

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4
Q

MOA

A

nonselectively Inhibits COX isoenzymes preventing the synthesis of prostaglandins and thromboxane

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5
Q

Indications / Clinical uses

A

Pain management
ERAS Protocols
Antipyretic?

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6
Q

IV dose

A

400-800 mg over 30 mins q6h

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7
Q

Pediatric IV dose (12-17 years)

A

400 mg over 30 mins q4-6h

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8
Q

Administration Safety note

A

MUST BE DILUTED PRIOR TO USE
- undiluted can cause hemolysis
- must be delivered slow and never as IV bolus or IM injection

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9
Q

MAX dose (daily)

A

3200 mg/day

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10
Q

Onset

A

30 mins

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11
Q

Duration

A

4-6 hours

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12
Q

Common SE ( > 5%)

A

N/V
flatulence
HA
hemorrhage
dizziness

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13
Q

Most common adverse reactions in peds (>/= 2%)

A

infusion site pain
N/V
anemia
HA

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14
Q

Hematologic effects

A

bleeding

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15
Q

GI effects

A

Gastropathy
GI bleeding
Peptic ulcer disease

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16
Q

CV effects

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A

HTN
HF exacerbation
increased risk of VTE, MI, and Stroke

17
Q

Renal effects

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A

induce reversible GFR impairment

18
Q

Skeletal effects

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A

Potential to inhibit bone formation and delay secondary bone healing

19
Q

Absolute contraindications

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A

KNOWN HYPERSENSITIVITY
- Anaphylactoid or serious skin reactions
Samter’s Triad (AERD)
- Asthma
- urticaria
- other allergic-type reactions after taking aspirin or other NSAIDs

Pregnancy after 30 weeks gestation

20
Q

Precautions

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A

CV disease
Peptic ulcer disease
GI bleeding
Liver disease
HTN
Heart failure

21
Q

Metabolism

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A

Extensive Hepatic
- CYP2C9

22
Q

Elimination

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A

Renal excretion

23
Q

Vd coniderations

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A

Small
- hydrophilic
- remains in plasma / ECF

24
Q

Clearance considerations

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A

Reduced by
- hepatic impairment
- elderly

25
Protein Binding
99% Albumin - very small free fraction is pharmacologically active
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