Dopamine

Question 1

Brand Name

Answer 1

Inotropin

Question 2

Indications

Answer 2

Former 1st line treatment for shock to Inprove CO, support BP, and maintain renal function

Question 3

MOA

Answer 3

Endogenous nonselective direct and indirect adrenergic and dopaminergic agonist

Lower dose (< 3 mcg/kg/min) activate D1 receptors to dilate renal, mesenteric, and splenic arterial blood vessels increasing Blood Flow, activate D2 receptors reducing NE release from pre and post ganglionic sympathetic neurons.

Higher doses > 10 mcg/kg/min: activate alpha-1 receptors increasing arterial pressure through arteriolar vasoconstriction

Question 4

Renal perfusion dose

Answer 4

0.5-3 mcg/kg/min

Question 5

CV stability dose

Answer 5

10-20 mcg/kg/min

Question 6

Important note

Answer 6

Chronotropic and proarrythmic effects limit its usefulness in some pts, largely replaced by NE or fendoldopam