Pregabalin

Question 1

Brand Name

Answer 1

Lyrica

Question 2

Broad Category

Answer 2

Analgesic Adjunct / Anticonvulsant

Question 3

Class

Answer 3

Gabapentinoid / Glutamate modulator

Question 4

MOA

Answer 4

Primary: binds to and blocks voltage-gated calcium channels and NMDA receptors
- diminished release of glutamate (Ca2+ blocking action)

Question 5

Indications

Answer 5

Diabetic neuropathy
Fibromyalgia
Chronic neuropathic pain
Multimodal post op pain management (ERAS)
anticonvulsant

Question 6

PO post-op pain dose (Barash)

Answer 6

25-50 mg BID

Question 7

onset

Answer 7

1 hour

Question 8

Duration

Answer 8

6-12 hours

Question 9

Common SE

Answer 9

sedation, dizziness, blurred vision, and peripheral edema

Question 10

Metabolism

Answer 10

Minimal

Question 11

Elimination

Answer 11

Renal unchanged