Fluoride

Question 1

Which spe is the most sensitive to Fluoride poisoning ?

Answer 1

Ru > P & poultry

Question 2

How is the absoprtion when the F is asso w/ Ca ?

Answer 2

Reduced

Question 3

Where does the F accumulate ?

Answer 3

In bone & teeth

Question 4

Action mecha of F :

Answer 4

HypoCa, high capillary permeability & inhibit enz
+ teratogenic
Bone & teeth -> OH –> hydroxyapatite
abn osteoblast mineralization
enz inhibition
Thyroid pb

Question 5

Acute F poisoning CS :

Answer 5

GI & hypoCa signs

Question 6

Chronic F poisoning CS :

Answer 6

bony alterations
teeth disturbances (dental lesions, mottled / Br enamel)
malnutrition

Question 7

Is there a spe ttt in F poisoning ? If yes, which one ?

Answer 7

Yes, ionized Ca in acute cases
Chronic = no spe ttt