1
Q
A
2
Q
How is the absorption for the inorga / orga Pb ?
A
Inorga = slow / incomplete
Orga = liposoluble, better GI & skin absorption
3
Q
Pb distribution in the body ?
A
Liver -> entero-hepatic recirc
4
Q
Which metals is accumulating in bony & hairy matter ?
A
Pb
5
Q
Pb action mecha :
A
SH binding enz prot & heme / ATP synth inhibition
Neurotoxic effect
Liver / kidney degeneration, growth depression, abortion, GI muc necro
6
Q
Main Pb poisoning CS :
A
Encephalopathy, GI malfunction
7
Q
Which diagnostic method is used to highlight Pb poisoning ?
A
Delta-aminlevulinic acid in urine
Blood/ tissue Pb levels
8
Q
A
9
Q
Spe antidote in Pb poisoning ? If yes, which one ?
A
CaNa2-EDTA
Toxico
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