Glomerulonephritis (GN)

Question 1

glomerulonephritis

Answer 1

glomerular inflm

• acute post-infectious (proliferative)
• various forms

Question 2

patho

Answer 2

• usually in children but not restricted
• Type III HS (viral or bacterial trigger) –> Ab-Ag complex deposited in glomerular capillaries
• proceeded by pharyngeal or dermal infection (7-12 days)
• Ab-Ag complex attaches to capillary walls –> blocking pores for filtration –> glomerular filtration impeded –> dec GFR –> acute nephritic syndrome

Question 3

characteristics of GN

Answer 3

• glomerular enlargement

- hypercellularity

Question 4

hypercellularity

Answer 4

• Inc in # of WBCs
• Inc in # of endothelial cells –> line capsule
• Inc in # of mesangial cells

Question 5

mesangial cells

Answer 5

• Specialized cells that cover 30% of glomerular capillaries
• Contract basement membrane of endothelium of glomerular capillaries –> dec SA of basement membrane –> dec GFR

Question 6

mnfts

Answer 6

• oliguria, proteinuria, hematuria (inflm damage)
• azotemia
• fluid retention

Question 7

azotemia

Answer 7

retain nitrogenous wastes

Question 8

fluid retention leads to which cmplx

Answer 8

HTN & edema

Question 9

recovery of GN

Answer 9

• usually self-limiting (several wks)

- must treat infection