T/F: In the Rx of gout, colchicine causes diarrhoea
True
T/F: Allopurinol is effective in an acute gout attack
False
T/F: Apirin in C/I in acute attacks
True
T/F: Colchicine causes constipation as an A/E
False, Diarrhoea
T/F: Allopurinol inhibits xanthine oxidase
True
T/F: Probenecid efficacy is opitmised in alkaline urine
True
T/F: Prenisone is C/I in gout
False
T/F: Colchicine causes diarrhoea
True
T/F: Probenicid is a xanthine ocidase inhibitor
False, its a uricose uric, thus inhibits URAT-1
T/F: Diclofenac reduces pain
True
T/F: Alkalinising the urine increases the excretion of uric acid
True
T/F: Colchicine is preferred to aspirin in the mx of gout
True
T/F: Colchicine inhibits uric acid metabolism
False
T/F: Colchicine increases uric acid excretion
False, inhibits cell movement & phagocytosis, release of inflammatory cytokines and arrests cell division
T/F: Colchicine causes diarrhoea
True
T/F: Colchicine is used as a prophylaxis for chronic gout
True
T/F: Probenicid inhibits the activity of XO
False
T/F: low dose aspirin has a uricosuric effect
False
T/F: the combination of colchicine & allopurinol is used in pts with chronic gout
True
T/F: Allopurinol inhibits the conversion of hypoxanthine to uric acid
True, Hypoxanthine → Xanthine → Uric acid. By inhibiting this enzyme, allopurinol reduces uric acid production
T/F: Diclofenac reduces inflammation in the gouty joint
True
