What is the MOA for methotrexate?
Inhibits DHFR
MOA for Etanercept?
TNFa inhibitor
MOA for Rutiximab?
B cell inhibitor (CD20)
MOA for Sulfasalazin?
Inhibits T cells activation
MOA for Leflunomide?
Inhibits dihydroorate dehydrogenase
T/F: NSAIDs prevent the formation of bone lesions?
False
T/F: Methotrexate is hepatotoxic
True
T/F: Hydrochloroquine increases the risk of ocular damage
True
T/F: Leflunomide is safe to use during pregnancy?
False - contraindicated in pregnancy, hypersensitivity, juvenile RA
T/F: Infliximab increases circulating TNFa levels
False - TNFa inhibitor
T/F: Rutiximab stimulates the formation of antibodies by B-cells
False - binds to CD20 on B cells to induce apoptysis
T/F: Etanercept binds to TNFa receptor
False - binds to free circulating TNFa molecules to inhibit it
T/F: Infliximab increases the risk for URTI
True - incl. methotrexate, sulfasalazin, JAK inhibitors & Amipremilast
T/F: Tocilizumab is safe to use in children
True - Rx for juvenile RA
T/F: Methotrexate A/E are reversed by folic acid
True
T/F: Infliximab stimulates the release of TNFa
False - inhibits TNFa
T/F: Methotrexate is a folic acid analogue
True - its an antimetabolite that inhibits dihydrofolate reductase (DHFR)
T/F: Methotrexate is a non-selective COX inhibitor
False
T/F: Prednisone reduces infammation in an inflamed joint
True
T/F: Leflunomide suppresses the immune system
False
T/F: Folic acid antagonises the action of methotrexate
True
T/F: Chloroquine causes ocular toxicity
True
T/F: Prednisone decreases inflammation in RA
True
T/F: Probenecid is used in the Rx of RA
False - gout
