TB

Question 1

T/F: Ethambutol is given as a prophylaxis to TB close contact

Answer 1

False - Rifapentine

Question 2

T/F: Rifampicin inhiits CYP450

Answer 2

False - Isoniazid

Question 3

T/F: Ethambutol is hepatotoxic

Answer 3

False - ototoxic

Question 4

T/F: Isoniazid inhibits protein synthesis

Answer 4

False - inhibits mycolic acid & DNA synthesis

Question 5

T/F: Rifampicin decreases the clinical effectiveness of warfirin

Answer 5

True

Question 6

T/F: Pyridoxine is used to Rx Isoniazid-induced peripheral neuropathy

Answer 6

True

Question 7

T/F: Ethambutol causes orange discolouration of urine

Answer 7

False - Rifampicin

Question 8

A pt is complaining of blurred vision. Which agent from the first line drug regimen is responsible for the effects

Answer 8

Ethambutol

Question 9

T/F: multidrug resistant TB is characterised by resistance to Rifampicin, Isoniazid and pyrazinamide

Answer 9

False - rifampicin & isoniazid alone

Question 10

T/F: Ethambutol is used for prophylaxis of against TB in individuals with a positive TB contact

Answer 10

False

Question 11

T/F: Ethambutol is hepatotoxic

Answer 11

False - ototoxic

Question 12

T/F: There are no effective drugs against XDR TB

Answer 12

False

Question 13

T/F: Isoniazid causes peripheral neuropathy

Answer 13

True

Question 14

T/F: Ethambutol inhibits mycobacterial RNA polymerase

Answer 14

False - Rifampicin. Ethambutol inhibits arabinsyl trasferase & cell wall synthesis

Question 15

T/F: Pyrazinamide decreases serum uric acid levels

Answer 15

False - causes hyperuricaemia

Question 16

T/F: Pyrazinamide is hepatotoxic

Answer 16

True

Question 17

T/F: Rifampicin discolours body secretions to red-orange

Answer 17

True

Question 18

T/F: S/E of Rifampicin is peripheral neuropathy

Answer 18

False, Isoniazid

Question 19

T/F: S/E of Isoniazid is urine discolouration

Answer 19

False, Rifampicin

Question 20

T/F: S/E of Pyrazinimide is blurred vision

Answer 20

False, ethambutol

Question 21

T/F: S/E of ethambutol is joint pain

Answer 21

True, incl hyperuriaemia & ototoxicity

Question 22

T/F: MOA of rifampicin is it inhibits DNA synthesis

Answer 22

True

Question 23

T/F: Moxifloxacin inhibits tioposomerase

Answer 23

True, -floxacins are fluoroquinolones

Question 24

T/F: Isioniazid inhibits mycolic acid

Answer 24

True

Question 25

T/F: Pyrazinamide inhibits TB pyrazinamidase

Answer 25

False, inhibits mycolic acid synthesis, fatty acid synthase & cell wall synthesis

Question 26

T/F: Ethambutol inhibits ATP synthase

Answer 26

False

Question 27

T/F: Vitamin B3 decreases the risk of developing peripheral neuropathy

Answer 27

False

Question 28

T/F: Vitamin B12 decreases the risk of developing peripheral neuropathy

Answer 28

True

Question 29

T/F: Folic acid decreases the risk of developing peripheral neuropathy

Answer 29

False

Question 30

T/F: Vit B6 decreases the risk of developing peripheral neuropathy

Answer 30

True

Question 31

T/F: Vit K decreases the risk of developing peripheral neuropathy

Answer 31

False

Question 32

T/F: Rifampicin, Pyrazinamide, Isoniazid & streptomycin is the preferred Rx for a TB-infected pregnant female who hasnt been previously treated for TB and who has normal liver & kidney fx

Answer 32

False, Streptomycin is ototoxic

Question 33

T/F: Rifampicin, Pyrazinamide, Isoniazid & Ethambutol is the preferred Rx for a TB-infected pregnant female who hasnt been previously treated for TB and who has normal liver & kidney fx

Answer 33

True

Question 34

T/F: Rifampicin, Pyrazinamide, Isoniazid & Gentamycin is the preferred Rx for a TB-infected pregnant female who hasnt been previously treated for TB and who has normal liver & kidney fx

Answer 34

False, Gentamycin is an aminoglycoside which is contraindicated in pregnancy

Question 35

T/F: Rifampicin, Pyrazinamide, Isoniazid & Moxifloxacin is the preferred Rx for a TB-infected pregnant female who hasnt been previously treated for TB and who has normal liver & kidney fx

Answer 35

False, Moxifloxacin is a Fluoroquinolone which is avoided in pregnancy

Question 36

T/F: Pyrazinamide, Isoniazid, Gentamycin & Co-trimoxazole is the preferred Rx for a TB-infected pregnant female who hasnt been previously treated for TB and who has normal liver & kidney fx

Answer 36

False