GCPR Signaling step # 1
Signaling molecule binds and activates GPCR
GPCR step #2
G-protein activated by GTP binding
GPCR Step # 3
GTP activates adenylyl cyclase
Step # 4
GTP activates adenylyl cyclase
5
ATP to cAMP by adenylyl cyclase
6
cAMP activate protein kinase A
7
PKA goes to nucleus acting as a transcription factor