Sensitivity Adjustments

Question 1

How do cells adjust their sensitivity to a signal?

Answer 1

1) The receptor can be endocytosed or 2) the receptor could be dephosphorylated

Question 2

How is the b-adrenergic receptor degraded?

Answer 2

Bark binds to ser residues on carboxyl terminus of receptor following GsBy dissociation causing phosphorylation; Barr binds to phosphorylated ser residues on carboxyl terminus of the receptor; receptor-arrestin complex enters the cell by endocytosis;