(NF-KB) multi-step cascade)

Question 1

Process

Answer 1

1) Cytokine binds to receptor on membrane (Normally NF-KB is bound to I-KB) in the cytoplasm 2) Receptor causes phosphorylation of I-KB through IKB kinase 3 ) I-KB ubiquinated and degraded 4) NF-KB NLS exposed and migrates to nucleus

Question 2

IKB

Answer 2

prevents NF-KB from migrating to the nucleus