Hydrocortisone

Question 1

Pharmacology and presentation of Hydrocortisone?

Answer 1

100mg Vial reconstituted with 2ml of saline/WfI

Hydrocortisone is an adrenocortical steroid that has an effect on a number of physiological processes, chiefly as an anti-inflammatory hormone (glucocorticoid) but at high doses water and electrolyte balances (mineralocorticoid). Hydrocortisone inhibits the accumulation of inflammatory cells at inflammation sites, phagocytosis, lysosomal enzyme release and synthesis and/or release of mediators of inflammation. Additionally, it prevents and suppresses cell mediated immune reactions.

Question 2

Indicators of Hydrocortisone?

• MASS

Answer 2

• Moderate to severe asthma
• Acute exacerbation of COPD
• Severe allergic reactions or anaphylaxis
• Symptomatic adrenal insufficiency, e.g. Addisonian Crisis

Question 3

Contraindications of Hydrocortisone?

Answer 3

• Known allergy

Question 4

Cautions of Hydrocortisone?

Answer 4

• Hypertension

Question 5

Side Effects of Hydrocortisone?

Answer 5

• NIL

Question 6

Dosing Regimes of Hydrocortisone?

Answer 6

• Adults for Asthma, COPD, Adrenal insufficiency = single dose 100mg IV/IM (slow push for IV)
• Adults for Anaphylaxis = single dose 200mg IV/IM (slow push for IV)

Question 7

Onset and duration of Hydrocortisone?

Answer 7

• Onset = 1-2hrs
• Duration = 6-12hrs