Innate Immunity

Question 1

Ability to recognize self from nonself and protect itself from harm

Answer 1

Immunity

Question 2

Role of first line of defense

Answer 2

Barrier into the body

Question 3

Role of skin

Answer 3

Salty, acidic, layers, hair, sheds

Question 4

First line of defense components

Answer 4

Skin and mucus membranes

Question 5

Role of mucus membranes

Answer 5

Thick, sticky, movement, lysozyme

Question 6

Second line of defense

Answer 6

White blood cells

Question 7

Scouts

Answer 7

macrophages and dendritic cells

Question 8

Engulfing pathogens and destroying them

Answer 8

Phagocytosis

Question 9

What do WBCs recognize about pathogens?

Answer 9

Teichoic acid, LPS, flagellum

Question 10

What do WBCs have for detection?

Answer 10

Toll like receptors (TLR)

Question 11

What do pathogens have that gets recognized?

Answer 11

Microbe associated molecular pattern (MAMP)

Question 12

What is the first step of phagocytosis?

Answer 12

Recognition and binding

Question 13

What is the second step of phagocytosis

Answer 13

Endocytosis

Question 14

Pathogen is brough into a WBC by a vesicle, known as phagosome

Answer 14

Endocytosis

Question 15

Third step of phagocytosis

Answer 15

Phagosome fuses with lysosome and is broken down

Question 16

Fourth step of phagocytosis

Answer 16

Phagolysosome moves to plasma membrane, expels debris

Question 17

Phagocytosis is mainly the job of these

Answer 17

Macrophages

Question 18

DC’s carry out phagocytosis and do this

Answer 18

Alert adaptive response

Question 19

WBCs that circulate in blood

Answer 19

Neutrophils, eosinophils, basophils,

Question 20

Two roles of neutrophils

Answer 20

1. Phagocytosis
2. Lyse self, release DNA to form net

Question 21

What kills a pathogen after it is in a net from a neutrophil?

Answer 21

Macrophage

Question 22

Contains antibody on a receptor protein

Answer 22

Eosinophil

Question 23

What does an eosinophil antibody attach to?

Answer 23

A large eukaryote

Question 24

What do eosinophils release?

Answer 24

Perforin and granzymes

Question 25

Role of basophils

Answer 25

Release chemokines for communication with other WBCs

Question 26

What detects activating vs inhibitory proteins on a host cell?

Answer 26

Natural killer cells

Question 27

More inhibitory than activating

Answer 27

Healthy cell

Question 28

More activating than inhibitory

Answer 28

Infected cell

Question 29

If host cell is infected, NK Cell...

Answer 29

Release perforin and granzymes

Question 30

What does cytokines do to epithelial cells?

Answer 30

Loosen connections and express adhesion molecules for WBCs to attach to