Lab Module 12

Question 1

Mustard gas:

A) Builds white blood cells
B) Creates a mitosis-friendly environment
C) Halts blood marrow production
D) Builds red blood cells

Answer 1

Correct Answer:
C) Halts blood marrow production

Question 2

According to this video, in what year were the first chemotherapy drugs released?

A) 1921
B) 1945
C) 1947
D) 1924

Answer 2

Correct Answer:
C) 1947

Question 3

In 2018, how many people world-wide received a cancer diagnosis?

A) 17 million
B) 800,000
C) 1 million
D) 2 billion

Answer 3

Correct Answer:
A) 17 million

Question 4

How many types of chemotherapy drugs are available today?

A) 100
B) 30
C) 10
D) 50

Answer 4

Correct Answer:
A) 100

Question 5

How does these cold caps help patients undergoing chemotherapy?

A) By increasing temperature around the head and constricting blood flow
B) It can be either of these
C) By reducing temperature around the head and constricting blood flow
D) By adding addition medication to the head region

Answer 5

Correct Answer:
C) By reducing temperature around the head and constricting blood flow

Question 6

Cancer cells and bone marrow both:

A) Neither of these
B) Replicate rapidly
C) Replicate slowly
D) Not applicable

Answer 6

Correct Answer:
B) Replicate rapidly

Question 7

According to the study, which of the following strategies showed promise in protecting mice from chemotherapy-induced nerve damage?

A) Blocking the stress alarm in immune cells
B) Administering higher doses of chemotherapy
C) Increasing inflammation to counteract nerve damage
D) Removing immune cells entirely

Answer 7

Correct Answer:
A) Blocking the stress alarm in immune cells

Question 8

What is the proposed mechanism by which chemotherapy leads to chemotherapy-induced peripheral neuropathy (CIPN)?

A) DIrect DNA damage in nerve cells
B) Excessive production of neurotransmitters causing nerve overexcitation
C) Suppression of immune cells, preventing nerve repair
D) Activation of a stress-sensing system in immune cells, triggering inflammation and nerve injury

Answer 8

Correct Answer:
D) Activation of a stress-sensing system in immune cells, triggering inflammation and nerve injury

Question 9

How did blocking IRE1α in immune cells affect mice treated with paclitaxel in the study?

A) It reduced inflammatory responses, lessened CIPN-like behaviors, and preserved nerve health.
B) It had no effect; CIPN symptoms persisted.
C) It caused immune cells to attack neurons directly.
D) It worsened nerve damage and increased pain sensitivity.

Answer 9

Correct Answer:
A) It reduced inflammatory responses, lessened CIPN-like behaviors, and preserved nerve health.

Question 10

What is the potential clinical application of these findings regarding the IRE1α-XBP1 pathway?

A) Using the pathway to directly regenerate damaged neurons after CIPN develops
B) Using the pathway as a biomarker in a blood test to identify patients at risk of CIPN before symptoms appear
C) Preventing immune cells from entering the bloodstream during chemotherapy
D) Eliminating the need for chemotherapy in gynecologic cancers

Answer 10

Correct Answer:
B) Using the pathway as a biomarker in a blood test to identify patients at risk of CIPN before symptoms appear