What does a methyl-deficient diet lead to?
Decrease in DNA methylation, loss in decreasing gene expression
Example of DNA methylation
Addition of a methyl group to the 5 -5-carbon of cytosine to form 5 5-methylcytosine
When we have high agouti expression
hypo methylated, low methylation
When we have low agouti expression
Hypermethylated, high methylation
What is maternal imprinting?
A biological process where a gene from the mother is silenced and the paternal one is expressed. (More methylated Gene is silenced).