MACROLIDES

Question 1

what are the macrolides?

Answer 1

erythromycin (IV/PO)
clarithromycin (PO)
azithromycin (IV/PO)
fidaxomicin (PO)

bacteriostatic, time dependent

Question 2

ribosomal subunit affected?

Answer 2

50s

Question 3

good against?

2nd line option against?

Answer 3

atypicals
-legionella, chlamydophilia, mycoplasma

t. palladium and borrelia burgdorferi

Question 4

clinical uses?

Answer 4

resp
chlamydial infections
gastroparesis
-erythromycin
H. pylori ulcers 
Mycobacterium avium complex

Question 5

QT prolongation?

Answer 5

yes

ototoxicity with IV infusion of erythromycin
hepatic
GI

Question 6

potent inhibitors of CYP3A4? which one is the exception?

Answer 6

erythromycin and clarithromycin

azithromycin

Question 7

indication of fidaxomicin?

Answer 7

C dif

inhibits RNA polymerase, bactericidal