NON-STATINS

Question 1

Things to consider before

adding?

Answer 1

Adherence and lifestyle
Statin intolerance
Control of other risk factors

Question 2

non-statin options

Answer 2

• Ezetimibe (Zetia)
• Bile acid resins
   -Cholestyramine
   -Colestipol
   -Colesevelam
• Niacin
• Fibrates
   -Fenofibrate (Tricor)
   -Gemfibrozil
• Omega-3-acid ethyl esters
• Mipomersen
• Lomitapide
• PCSK9 inhibitors

Question 3

LDL remains at or above _____? clinicians may consider adding _____?

If LDL remains elevated, it is reasonable to add a??

Answer 3

70 mg/dL despite maximal statin therapy

ezetimibe***

PCSK9 inhibitor***

Question 4

Ezetimibe MOA?

combine with what?

Effectiveness?

ADRs and precaution?

Answer 4

Cholesterol Absorption Inhibitor that inhibits a transport protein (NPC1L1) in the small intestines, reducing cholesterol absorption

Combine with statins for additional LDL lowering

Reduction in LDL: 15%-20%

May elevate hepatic transaminases: discontinue if ALT or AST persistently ≥3 x ULN
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