1
Q
Magnesium
Mechanism of Action
A
- Competitive antagonist at the hippocampal presynaptic Ca²⁺ channel → reducing calcium-dependent release of neurotransmitters in the CNS (↓ ACh & Glutamate)
- Reduces hyperalgesia by decreasing central sensitization (NMDA antagonism)
- Suppresses neuropathic pain and attenuates postoperative pain
- Potentiates opioid effects
Tmac’s Version
2
Q
Class
A
NMDA receptor antagonist;
Antidysrhythmic, V
3
Q
Magnesium
Induction Dose: None
A
None
4
Q
Magnesium
Gtt rate
A
50 mg/kg over 15-30min preoperatively
8 mg/kg/hr intraoperatively
4
Q
Bolus Dose
A
1 Gm over 15-30 min
5
Q
Magnesium
Common Side Effects / Contraindications
A
Bradycardia, Burning pain on injection, Drowsiness, Dizziness, Flushing, Headache, Hypotension, Muscle weakness, Nausea /
Severe hypermagnesemia can result in: QRS widening, Decreased DTR, Respiratory depression
Treatment: Calcium gluconate 10-15mg/kg, Diuresis, Dialysis
6
Q
Magnesium
Onset
A
<1 min
7
Q
Magnesium
Peak
A
30 min
8
Q
Magnesium
Distribution half-life (t1/2α): None
A
None
9
Q
Magnesium
Metabolism: None
A
None
10
Q
Magnesium
Elimination half-life / Active metabolites (t1/2β)
A
28 hrs
Pharmacology II
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