What are the 5 plasmodium species?
P. Vivax P. Falciparum P.ovale P. Malariae P. Knowlesi
Life cycle of malaria?
Osmosis
IP and fever paroxysms?
P.vivax,p.ovale- IP- 10-12 days 48 hrs tertian fever P.malariae IP- 18-40 days 72 hrs quartran fever P.falciparum IP- 7-10 days Variable malignant tertian fever
Stages of febrile?
Cold stage- 15-60 min intense cold and uncontrollable shivering
Hot stage- 2-6 hrs intensely high fever, severe headache, N, V
Sweating stage- drenched in sweat, temp drops rapidly
Signs and symptoms?
Signs-4
Symptoms- 11
Complications?
10
Ix?
Serial thin and thick film (main) Rapid stick test Hemolytic anemia,thrombocytopenia DIC,hypoglycemia, lactic acidosis BU N SE (RF) Urinanalysis -haemoglobinuria,proteinuria, cells
Mx?
1.mono infection by v.vivax Chloroquine 3 days Primaquine for 14 days 2.mono infection by p.falciparum (uncomplicated) Artemisinin based combination therapy (ACT) Single dose of primaquine 3.complicated (above) IV artesunate ACT single dose primaquine
P.vivax and p.falci difference?
5