med admin

Question 1

pharmacokinetics

Answer 1

The process of drug movement throughout the body that allows for the drug to act

Question 2

absorption

Answer 2

The process by which a drug passes into the bloodstream

Question 3

what affects drug absorption

Answer 3

-Route of administration

-Ability of medication to disintegrate and/or dissolve

-Movement of drug from site of administration into the blood

Question 4

distribution

Answer 4

movement of the drug out of the bloodstream and into the body tissues

Question 5

distribution is affected by

Answer 5

circulation
membrane permeability
blood brain barrier
protein binding

Question 6

metabolism

Answer 6

process by which the body chemically changes the drug into a form that can be excreted

Question 7

primary organ for drug metabolism

Answer 7

the liver

Question 8

first pass effect 5 steps

Answer 8

1. oral drug taken by patient
2. drug absorbed across intestinal mucosa
3. drug enters portal circulation + travel
4. drug is metabolized to less active forms on FIRST PASS
5. drug metabolites leaves the liver to distribute to the tissues

Question 9

excretion

Answer 9

process by which drugs are eliminated from the body

Question 10

primary organ excretion

Answer 10

kidneys

Question 11

pharmacodynamics

Answer 11

the study of the effects of drugs in the body

Question 12

therapeutic effect

Answer 12

the intended, beneficial action of a drug

Question 13

therapeutic range

Answer 13

Range of doses that produce therapeutic response without causing adverse effects

Question 14

analgesic

Answer 14

painkiller

Question 15

primary effects

Answer 15

the intended effect/what we wanted to happen

Question 16

secondary effects

Answer 16

other things that happen/can be good or bad

Question 17

what do you monitor for liver failure

Answer 17

toxicity

Question 18

side effects vs adverse drug reactions

Answer 18

SE: predictable things that can happen as a result oftaking a drug

AD: unintentional, unexpected reactions to a drug. ALWAYS undesirable

Question 19

onset

Answer 19

how long after ingestion the medication starts working

Question 20

peak

Answer 20

The highest plasma concentration of the drug (after absorption)

Question 21

trough

Answer 21

The lowest plasma concentration of the drug (after absorption)

Question 22

duration

Answer 22

how long the drug lasts before it falls below the minimum effective concentration

Question 23

additive effects

Answer 23

Giving 2 drugs at once = the sum of the effects of the two
1 + 2 = 3

Question 24

synergistic effects

Answer 24

Giving 2 drugs at once = a dramatic increase in the effects of both

Question 25

potentiation

Answer 25

Giving 2 drugs at once = one makes the other one stronger

Question 26

agonist vs antagonist

Answer 26

agonist: binds to a receptor and mimics a lot of the ligand's action antagonist: blocks the action of a ligand

Question 27

half life

Answer 27

how long it takes for a drug to get rid of 1/2 of whats there