Methoxyflurane

Question 1

How does Methoxyflurane present?

Answer 1

3mL

Question 2

What are the pharmacodynamics of Methoxyflurane?

Answer 2

• Interferes with release and re-uptake of neurotransmitters at post-synaptic terminals
• Activates inhibitory receptor (GABA)
• Induces muscle relaxation

Question 3

When is Methoxyflurane indicated?

Answer 3

• Pain

Question 4

Methoxyflurane Contraindications?

Answer 4

• Pre-existing renal disease (Transforms into fluoride -> reduced kidney function leads to build up of Fluoride -> inhibition of tubular reabsorption -> disruption to collagen synthesis -> Renal damage
• Malignant Hyperthermia (Anaesthetics can induced Fatal Hyperthermia, rigid muscles/spasms

Question 5

Methoxyflurance Precautions?

Answer 5

• no more than 6mL in the last 24hours
• Methoxy should not be administered in a confined space

Question 6

Methoxyflurane adverse effects

Answer 6

• CNS: Dizziness, Drowsiness
• CV: Hypotension
• GIT: Nausea and vomiting