Morphine

Question 1

How does Morphine present

Answer 1

10mg/1mL

Question 2

Pharmacodynamics of Morphine

Answer 2

• Bind to Kappa, Mu receptors
• Mimics action of opioid peptides and antagonises to stimulate pain centres in CNS and spinal cord

Question 3

Morphine Contraindications

Answer 3

• Hypersensitivity
• Renal Impairment/failure
• Late second stage labour

Question 4

Morphine Precautions (8 Things)

Answer 4

1. Elderly/frail
2. Hypotension
3. Respiratory Depression
4. Current Asthma
5. Respiratory tract burns
6. Known Addiction to opioids
7. Acute alcholism
8. Patients on MAOIs

Question 5

Morphine Adverse effects

Answer 5

CNS: Drowsiness, respiratory depression, Euphoria, N+V, Addiction, Pin-point pupiles

Cardiovascular: Hypotension, Bradycardia

Question 6

Why is Morphine contraindicated in renal Impairment?

Answer 6

• Accumulation of Metabolites M3G and M6G mediates CNS depression and wont be cleared quick enough in renally impaired patients

Question 7

Why is morphine contraindicated in late second stage labour?

Answer 7

• Can cross the placental barrier and cause a baby to be born apnoeic

Question 8

After Morphine injection is whealts at the IV site a sign of Anaphylaxis?

Answer 8

No (Histamine release)