Midazolam

Question 1

How does Midazolam present

Answer 1

5mg/1mL

Question 2

Pharmacodynamics of Midazolam

Answer 2

Binds to GABA receptors -> Increases Cl- into the cell -> leads to hyperpolarization -> leads to neural inhibition

Question 3

Midazolam Contraindications

Answer 3

• Hypersensitivity

Question 4

Midazolam precautions

Answer 4

• Redued dose required for hte elderly, frail, renal failure, CCF, or shock
• CNS depressant effects of benzo are enhanced in the presence of narcotics and alcohol
• Can cause severe respiratory depression in patients with COPD
• Patients with myasthenia gravis (Due to weak muscles and ability for midazolam to depress respiratory muscles)

Question 5

Midazolam Onset

Answer 5

IM - 3-5minutes
IV - 1-3Minutes

Question 6

Midazolam Adverse effects

Answer 6

• Depression level of consciousness
• Respiratory depression
• Loss of airway control
• Hypotension